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Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.
Yoo E, Stokes BH, de Jong H, Vanaerschot M, Kumar T, Lawrence N, Njoroge M, Garcia A, Van der Westhuyzen R, Momper JD, Ng CL, Fidock DA, Bogyo M. Yoo E, et al. Among authors: bogyo m. J Am Chem Soc. 2018 Sep 12;140(36):11424-11437. doi: 10.1021/jacs.8b06656. Epub 2018 Aug 29. J Am Chem Soc. 2018. PMID: 30107725 Free PMC article.
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents.
Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA. Stokes BH, et al. Among authors: bogyo m. PLoS Pathog. 2019 Jun 6;15(6):e1007722. doi: 10.1371/journal.ppat.1007722. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31170268 Free PMC article.
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites.
Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, Linington RG, Long JZ, Uhlemann AC, Weerapana E, Fidock DA, Bogyo M. Yoo E, et al. Among authors: bogyo m. Cell Chem Biol. 2020 Feb 20;27(2):143-157.e5. doi: 10.1016/j.chembiol.2020.01.001. Epub 2020 Jan 23. Cell Chem Biol. 2020. PMID: 31978322 Free PMC article.
Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum.
Bennett JM, Ward KE, Muir RK, Kabeche S, Yoo E, Yeo T, Lam G, Zhang H, Almaliti J, Berger G, Faucher FF, Lin G, Gerwick WH, Yeh E, Fidock DA, Bogyo M. Bennett JM, et al. Among authors: bogyo m. ACS Infect Dis. 2023 Oct 13;9(10):2036-2047. doi: 10.1021/acsinfecdis.3c00310. Epub 2023 Sep 15. ACS Infect Dis. 2023. PMID: 37712594
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets.
Bennett JM, Narwal SK, Kabeche S, Abegg D, Hackett F, Yeo T, Li VL, Muir RK, Faucher FF, Lovell S, Blackman MJ, Adibekian A, Yeh E, Fidock DA, Bogyo M. Bennett JM, et al. Among authors: bogyo m. bioRxiv [Preprint]. 2024 Jan 11:2024.01.11.575224. doi: 10.1101/2024.01.11.575224. bioRxiv. 2024. PMID: 38260474 Free PMC article. Preprint.
303 results