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8-Prenyl naringenin is a potent ERalpha selective phytoestrogen present in hops and beer.
Schaefer O, Hümpel M, Fritzemeier KH, Bohlmann R, Schleuning WD. Schaefer O, et al. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):359-60. doi: 10.1016/s0960-0760(03)00050-5. J Steroid Biochem Mol Biol. 2003. PMID: 12711023 No abstract available.
Characterization of new estrogen receptor destabilizing compounds: effects on estrogen-sensitive and tamoxifen-resistant breast cancer.
Hoffmann J, Bohlmann R, Heinrich N, Hofmeister H, Kroll J, Künzer H, Lichtner RB, Nishino Y, Parczyk K, Sauer G, Gieschen H, Ulbrich HF, Schneider MR. Hoffmann J, et al. J Natl Cancer Inst. 2004 Feb 4;96(3):210-8. doi: 10.1093/jnci/djh022. J Natl Cancer Inst. 2004. PMID: 14759988
In vivo characterization of estrogen receptor modulators with reduced genomic versus nongenomic activity in vitro.
Otto C, Fuchs I, Altmann H, Klewer M, Schwarz G, Bohlmann R, Nguyen D, Zorn L, Vonk R, Prelle K, Osterman T, Malmström C, Fritzemeier KH. Otto C, et al. J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):95-100. doi: 10.1016/j.jsbmb.2008.05.003. Epub 2008 Jul 7. J Steroid Biochem Mol Biol. 2008. PMID: 18606537
Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.
Lücking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, Briem H, Terebesi I, Meyer K, Prelle K, Denner K, Bömer U, Schäfer M, Eis K, Valencia R, Ince S, von Nussbaum F, Mumberg D, Ziegelbauer K, Klebl B, Choidas A, Nussbaumer P, Baumann M, Schultz-Fademrecht C, Rühter G, Eickhoff J, Brands M. Lücking U, et al. Among authors: bohlmann r. ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16. ChemMedChem. 2017. PMID: 28961375 Free PMC article.
Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties.
Hartung IV, Hammer S, Hitchcock M, Neuhaus R, Scholz A, Siemeister G, Bohlmann R, Hillig RC, Pühler F. Hartung IV, et al. Among authors: bohlmann r. Bioorg Med Chem Lett. 2016 Jan 1;26(1):186-93. doi: 10.1016/j.bmcl.2015.11.004. Epub 2015 Nov 3. Bioorg Med Chem Lett. 2016. PMID: 26611920
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
Schulze VK, Klar U, Kosemund D, Wengner AM, Siemeister G, Stöckigt D, Neuhaus R, Lienau P, Bader B, Prechtl S, Holton SJ, Briem H, Marquardt T, Schirok H, Jautelat R, Bohlmann R, Nguyen D, Fernández-Montalván AE, Bömer U, Eberspaecher U, Brüning M, Döhr O, Raschke M, Kreft B, Mumberg D, Ziegelbauer K, Brands M, von Nussbaum F, Koppitz M. Schulze VK, et al. Among authors: bohlmann r. J Med Chem. 2020 Aug 13;63(15):8025-8042. doi: 10.1021/acs.jmedchem.9b02035. Epub 2020 Apr 27. J Med Chem. 2020. PMID: 32338514
To join or not to join.
Bohlmann RC. Bohlmann RC. MGMA Connex. 2015 Jan-Feb;15(1):26-7. MGMA Connex. 2015. PMID: 26647515 No abstract available.
Is bigger better? The good, the bad and the ugly.
Bohlmann RC. Bohlmann RC. MGMA Connex. 2014 Jan;14(1):39, 41. MGMA Connex. 2014. PMID: 25167645 No abstract available.
Is it flirtation or real love?
Bohlmann RC. Bohlmann RC. MGMA Connex. 2013 Nov-Dec;13(10):45. MGMA Connex. 2013. PMID: 24319874 No abstract available.
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