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Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Azzu V, et al. Mol Metab. 2021 Jun;48:101210. doi: 10.1016/j.molmet.2021.101210. Epub 2021 Mar 17. Mol Metab. 2021. PMID: 33722690 Free PMC article.
Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.
Lindén D, Ahnmark A, Pingitore P, Ciociola E, Ahlstedt I, Andréasson AC, Sasidharan K, Madeyski-Bengtson K, Zurek M, Mancina RM, Lindblom A, Bjursell M, Böttcher G, Ståhlman M, Bohlooly-Y M, Haynes WG, Carlsson B, Graham M, Lee R, Murray S, Valenti L, Bhanot S, Åkerblad P, Romeo S. Lindén D, et al. Mol Metab. 2019 Apr;22:49-61. doi: 10.1016/j.molmet.2019.01.013. Epub 2019 Feb 5. Mol Metab. 2019. PMID: 30772256 Free PMC article.
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Carobbio S, et al. Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. Diabetes. 2013. PMID: 23919961 Free PMC article.
PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD.
Grimaudo S, Bartesaghi S, Rametta R, Marra F, Margherita Mancina R, Pihlajamäki J, Kakol-Palm D, Andréasson AC, Dongiovanni P, Ludovica Fracanzani A, Lori G, Männistö V, Pellegrini G, Bohlooly-Y M, Pennisi G, Maria Pipitone R, Spagnuolo R, Craxì A, Lindén D, Valenti L, Romeo S, Petta S. Grimaudo S, et al. Liver Int. 2021 Feb;41(2):321-332. doi: 10.1111/liv.14711. Epub 2020 Nov 2. Liver Int. 2021. PMID: 33091218
IDOL regulates systemic energy balance through control of neuronal VLDLR expression.
Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Andersén H, Rajbhandari P, Porritt M, Carreras A, Ahnmark A, Seeliger F, Maxvall I, Eliasson P, Althage M, Åkerblad P, Lindén D, Cole TA, Lee R, Boyd H, Bohlooly-Y M, Correa SM, Yang X, Tontonoz P, Hong C. Lee SD, et al. Nat Metab. 2019 Nov;1(11):1089-1100. doi: 10.1038/s42255-019-0127-7. Epub 2019 Oct 28. Nat Metab. 2019. PMID: 32072135 Free PMC article.
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