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The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
Evans R, Bolduc PN, Pfaffenbach M, Gao F, May-Dracka T, Fang T, Hopkins BT, Chodaparambil JV, Henry KL, Li P, Metrick C, Nelson A, Trapa P, Thomas A, Burkly L, Peterson EA. Evans R, et al. Among authors: bolduc pn. J Med Chem. 2024 Mar 28;67(6):4676-4690. doi: 10.1021/acs.jmedchem.3c02226. Epub 2024 Mar 11. J Med Chem. 2024. PMID: 38467640
Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling.
Laudadio G, Neigenfind P, Chebolu R, Blasczak VD, Maddirala SJ, Palkowitz MD, Bolduc PN, Nicastri MC, Puthukanoori RK, Paraselli BR, Baran PS. Laudadio G, et al. Among authors: bolduc pn. Org Lett. 2024 Mar 22;26(11):2276-2281. doi: 10.1021/acs.orglett.4c00474. Epub 2024 Mar 11. Org Lett. 2024. PMID: 38467055
Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers.
Laudadio G, Neigenfind P, Péter Á, Rubel CZ, Emmanuel MA, Oderinde MS, Ewing TE, Palkowitz MD, Sloane JL, Gillman KW, Ridge D, Mandler MD, Bolduc PN, Nicastri MC, Zhang B, Clementson S, Petersen NN, Martín-Gago P, Mykhailiuk P, Engle KM, Baran PS. Laudadio G, et al. Among authors: bolduc pn. Angew Chem Int Ed Engl. 2024 Feb 19;63(8):e202314617. doi: 10.1002/anie.202314617. Epub 2024 Jan 18. Angew Chem Int Ed Engl. 2024. PMID: 38181042
Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling.
Zhang B, He J, Gao Y, Levy L, Oderinde MS, Palkowitz MD, Dhar TGM, Mandler MD, Collins MR, Schmitt DC, Bolduc PN, Chen T, Clementson S, Petersen NN, Laudadio G, Bi C, Kawamata Y, Baran PS. Zhang B, et al. Among authors: bolduc pn. Nature. 2023 Nov;623(7988):745-751. doi: 10.1038/s41586-023-06677-2. Epub 2023 Oct 3. Nature. 2023. PMID: 37788684
42 results