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Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase.
Liuzzi M, Mason SW, Cartier M, Lawetz C, McCollum RS, Dansereau N, Bolger G, Lapeyre N, Gaudette Y, Lagacé L, Massariol MJ, Dô F, Whitehead P, Lamarre L, Scouten E, Bordeleau J, Landry S, Rancourt J, Fazal G, Simoneau B. Liuzzi M, et al. Among authors: bolger g. J Virol. 2005 Oct;79(20):13105-15. doi: 10.1128/JVI.79.20.13105-13115.2005. J Virol. 2005. PMID: 16189012 Free PMC article.
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bös M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagacé L, LaPlante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St George R, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinàs-Brunet M. Lamarre D, et al. Among authors: bolger g. Nature. 2003 Nov 13;426(6963):186-9. doi: 10.1038/nature02099. Epub 2003 Oct 26. Nature. 2003. PMID: 14578911 Free article. Clinical Trial.
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
White PW, Llinàs-Brunet M, Amad M, Bethell RC, Bolger G, Cordingley MG, Duan J, Garneau M, Lagacé L, Thibeault D, Kukolj G. White PW, et al. Among authors: bolger g. Antimicrob Agents Chemother. 2010 Nov;54(11):4611-8. doi: 10.1128/AAC.00787-10. Epub 2010 Sep 7. Antimicrob Agents Chemother. 2010. PMID: 20823284 Free PMC article.
The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.
Duan J, Bolger G, Garneau M, Amad M, Batonga J, Montpetit H, Otis F, Jutras M, Lapeyre N, Rhéaume M, Kukolj G, White PW, Bethell RC, Cordingley MG. Duan J, et al. Among authors: bolger g. Antimicrob Agents Chemother. 2012 Oct;56(10):5381-6. doi: 10.1128/AAC.01028-12. Epub 2012 Aug 6. Antimicrob Agents Chemother. 2012. PMID: 22869578 Free PMC article.
183 results