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The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model.
Takano J, Maeda K, Bolger MB, Sugiyama Y. Takano J, et al. Among authors: bolger mb. Drug Metab Dispos. 2016 Nov;44(11):1808-1818. doi: 10.1124/dmd.116.070011. Epub 2016 Aug 18. Drug Metab Dispos. 2016. PMID: 27538919
Predicting the impact of physiological and biochemical processes on oral drug bioavailability.
Agoram B, Woltosz WS, Bolger MB. Agoram B, et al. Among authors: bolger mb. Adv Drug Deliv Rev. 2001 Oct 1;50 Suppl 1:S41-67. doi: 10.1016/s0169-409x(01)00179-x. Adv Drug Deliv Rev. 2001. PMID: 11576695 Review.
In silico modeling for the nonlinear absorption kinetics of UK-343,664: a P-gp and CYP3A4 substrate.
Abuasal BS, Bolger MB, Walker DK, Kaddoumi A. Abuasal BS, et al. Among authors: bolger mb. Mol Pharm. 2012 Mar 5;9(3):492-504. doi: 10.1021/mp200275j. Epub 2012 Feb 2. Mol Pharm. 2012. PMID: 22264132
Modeling of absorption.
Woltosz WS, Bolger MB, Lukacova V. Woltosz WS, et al. Among authors: bolger mb. Methods Mol Biol. 2012;929:313-36. doi: 10.1007/978-1-62703-050-2_13. Methods Mol Biol. 2012. PMID: 23007435
PBPK models for the prediction of in vivo performance of oral dosage forms.
Kostewicz ES, Aarons L, Bergstrand M, Bolger MB, Galetin A, Hatley O, Jamei M, Lloyd R, Pepin X, Rostami-Hodjegan A, Sjögren E, Tannergren C, Turner DB, Wagner C, Weitschies W, Dressman J. Kostewicz ES, et al. Among authors: bolger mb. Eur J Pharm Sci. 2014 Jun 16;57:300-21. doi: 10.1016/j.ejps.2013.09.008. Epub 2013 Sep 21. Eur J Pharm Sci. 2014. PMID: 24060672 Review.
Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data.
Lukacova V, Woltosz WS, Bolger MB. Lukacova V, et al. Among authors: bolger mb. AAPS J. 2009 Jun;11(2):323-34. doi: 10.1208/s12248-009-9107-2. Epub 2009 May 9. AAPS J. 2009. PMID: 19430911 Free PMC article.
Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine.
Bolger MB, Lukacova V, Woltosz WS. Bolger MB, et al. AAPS J. 2009 Jun;11(2):353-63. doi: 10.1208/s12248-009-9111-6. Epub 2009 May 12. AAPS J. 2009. PMID: 19434502 Free PMC article.
Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series.
Daga PR, Bolger MB, Haworth IS, Clark RD, Martin EJ. Daga PR, et al. Among authors: bolger mb. Mol Pharm. 2018 Mar 5;15(3):821-830. doi: 10.1021/acs.molpharmaceut.7b00972. Epub 2018 Feb 1. Mol Pharm. 2018. PMID: 29337578
In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect.
Tubic M, Wagner D, Spahn-Langguth H, Bolger MB, Langguth P. Tubic M, et al. Among authors: bolger mb. Pharm Res. 2006 Aug;23(8):1712-20. doi: 10.1007/s11095-006-9020-7. Pharm Res. 2006. PMID: 16832615
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds.
Margolskee A, Darwich AS, Pepin X, Pathak SM, Bolger MB, Aarons L, Rostami-Hodjegan A, Angstenberger J, Graf F, Laplanche L, Müller T, Carlert S, Daga P, Murphy D, Tannergren C, Yasin M, Greschat-Schade S, Mück W, Muenster U, van der Mey D, Frank KJ, Lloyd R, Adriaenssen L, Bevernage J, De Zwart L, Swerts D, Tistaert C, Van Den Bergh A, Van Peer A, Beato S, Nguyen-Trung AT, Bennett J, McAllister M, Wong M, Zane P, Ollier C, Vicat P, Kolhmann M, Marker A, Brun P, Mazuir F, Beilles S, Venczel M, Boulenc X, Loos P, Lennernäs H, Abrahamsson B. Margolskee A, et al. Among authors: bolger mb. Eur J Pharm Sci. 2017 Jan 1;96:598-609. doi: 10.1016/j.ejps.2016.09.027. Epub 2016 Sep 23. Eur J Pharm Sci. 2017. PMID: 27671970
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