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Page 1
Low archaeal diversity linked to subseafloor geochemical processes at the Lost City Hydrothermal Field, Mid-Atlantic Ridge.
Schrenk MO, Kelley DS, Bolton SA, Baross JA. Schrenk MO, et al. Among authors: bolton sa. Environ Microbiol. 2004 Oct;6(10):1086-95. doi: 10.1111/j.1462-2920.2004.00650.x. Environ Microbiol. 2004. PMID: 15344934
Diversity among three novel groups of hyperthermophilic deep-sea Thermococcus species from three sites in the northeastern Pacific Ocean.
Holden JF, Takai K, Summit M, Bolton S, Zyskowski J, Baross JA. Holden JF, et al. FEMS Microbiol Ecol. 2001 Jun;36(1):51-60. doi: 10.1111/j.1574-6941.2001.tb00825.x. FEMS Microbiol Ecol. 2001. PMID: 11377773
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Bolton SA, Sutton JC, Anumula R, Bisacchi GS, Jacobson B, Slusarchyk WA, Treuner UD, Wu SC, Zhao G, Pi Z, Sheriff S, Smirk RA, Bisaha S, Cheney DL, Wei A, Schumacher WA, Hartl KS, Liu E, Zahler R, Seiler SM. Bolton SA, et al. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5239-43. doi: 10.1016/j.bmcl.2013.06.028. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23927973
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
Li J, Kennedy LJ, Shi Y, Tao S, Ye XY, Chen SY, Wang Y, Hernández AS, Wang W, Devasthale PV, Chen S, Lai Z, Zhang H, Wu S, Smirk RA, Bolton SA, Ryono DE, Zhang H, Lim NK, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Kadiyala P, Hosagrahara V, Zhang L, Xu C, Li YX, Muckelbauer JK, Chang C, An Y, Krystek SR, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA. Li J, et al. Among authors: bolton sa. J Med Chem. 2010 Apr 8;53(7):2854-64. doi: 10.1021/jm9016812. J Med Chem. 2010. PMID: 20218621
Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Sutton JC, Bolton SA, Davis ME, Hartl KS, Jacobson B, Mathur A, Ogletree ML, Slusarchyk WA, Zahler R, Seiler SM, Bisacchi GS. Sutton JC, et al. Among authors: bolton sa. Bioorg Med Chem Lett. 2004 May 3;14(9):2233-9. doi: 10.1016/j.bmcl.2004.02.012. Bioorg Med Chem Lett. 2004. PMID: 15081015
Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.
Bisacchi GS, Slusarchyk WA, Bolton SA, Hartl KS, Jacobs G, Mathur A, Meng W, Ogletree ML, Pi Z, Sutton JC, Treuner U, Zahler R, Zhao G, Seiler SM. Bisacchi GS, et al. Among authors: bolton sa. Bioorg Med Chem Lett. 2004 May 3;14(9):2227-31. doi: 10.1016/j.bmcl.2004.02.011. Bioorg Med Chem Lett. 2004. PMID: 15081014
Synthesis of potent and selective 2-azepanone inhibitors of human tryptase.
Zhao G, Bolton SA, Kwon C, Hartl KS, Seiler SM, Slusarchyk WA, Sutton JC, Bisacchi GS. Zhao G, et al. Among authors: bolton sa. Bioorg Med Chem Lett. 2004 Jan 19;14(2):309-12. doi: 10.1016/j.bmcl.2003.11.016. Bioorg Med Chem Lett. 2004. PMID: 14698147
Synthesis of potent and highly selective inhibitors of human tryptase.
Slusarchyk WA, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Sutton JC, Treuner U, Zahler R, Zhao G, Bisacchi GS. Slusarchyk WA, et al. Among authors: bolton sa. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8. doi: 10.1016/s0960-894x(02)00689-3. Bioorg Med Chem Lett. 2002. PMID: 12372541
Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Sutton JC, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Slusarchyk WA, Treuner U, Zahler R, Zhao G, Bisacchi GS. Sutton JC, et al. Among authors: bolton sa. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33. doi: 10.1016/s0960-894x(02)00688-1. Bioorg Med Chem Lett. 2002. PMID: 12372540
Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa.
Klein SI, Czekaj M, Gardner CJ, Guertin KR, Cheney DL, Spada AP, Bolton SA, Brown K, Colussi D, Heran CL, Morgan SR, Leadley RJ, Dunwiddie CT, Perrone MH, Chu V. Klein SI, et al. Among authors: bolton sa. J Med Chem. 1998 Feb 12;41(4):437-50. doi: 10.1021/jm970482y. J Med Chem. 1998. PMID: 9484495
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