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Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation.
Comella-Bolla A, Orlandi JG, Miguez A, Straccia M, García-Bravo M, Bombau G, Galofré M, Sanders P, Carrere J, Segovia JC, Blasi J, Allen ND, Alberch J, Soriano J, Canals JM. Comella-Bolla A, et al. Among authors: bombau g. Mol Neurobiol. 2020 Jun;57(6):2766-2798. doi: 10.1007/s12035-020-01907-4. Epub 2020 Apr 30. Mol Neurobiol. 2020. PMID: 32356172 Free PMC article.
Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons.
Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, Rosser AE, Canals JM. Straccia M, et al. Among authors: bombau g. Mol Ther Methods Clin Dev. 2015 Sep 16;2:15030. doi: 10.1038/mtm.2015.30. eCollection 2015. Mol Ther Methods Clin Dev. 2015. PMID: 26417608 Free PMC article.
Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, Joy S, Badder L, Connor-Robson N, Comella A, Straccia M, Bombau G, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ. Telezhkin V, et al. Among authors: bombau g. Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C520-41. doi: 10.1152/ajpcell.00166.2015. Epub 2015 Dec 30. Am J Physiol Cell Physiol. 2016. PMID: 26718628 Free article.
Soluble mutant huntingtin drives early human pathogenesis in Huntington's disease.
Miguez A, Gomis C, Vila C, Monguió-Tortajada M, Fernández-García S, Bombau G, Galofré M, García-Bravo M, Sanders P, Fernández-Medina H, Poquet B, Salado-Manzano C, Roura S, Alberch J, Segovia JC, Allen ND, Borràs FE, Canals JM. Miguez A, et al. Among authors: bombau g. Cell Mol Life Sci. 2023 Aug 3;80(8):238. doi: 10.1007/s00018-023-04882-w. Cell Mol Life Sci. 2023. PMID: 37535170 Free PMC article.