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Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.
Ramos YF, den Hollander W, Bovée JV, Bomer N, van der Breggen R, Lakenberg N, Keurentjes JC, Goeman JJ, Slagboom PE, Nelissen RG, Bos SD, Meulenbelt I. Ramos YF, et al. Among authors: bomer n. PLoS One. 2014 Jul 23;9(7):e103056. doi: 10.1371/journal.pone.0103056. eCollection 2014. PLoS One. 2014. PMID: 25054223 Free PMC article.
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.
Bomer N, den Hollander W, Ramos YF, Bos SD, van der Breggen R, Lakenberg N, Pepers BA, van Eeden AE, Darvishan A, Tobi EW, Duijnisveld BJ, van den Akker EB, Heijmans BT, van Roon-Mom WM, Verbeek FJ, van Osch GJ, Nelissen RG, Slagboom PE, Meulenbelt I. Bomer N, et al. Ann Rheum Dis. 2015 Aug;74(8):1571-9. doi: 10.1136/annrheumdis-2013-204739. Epub 2014 Apr 2. Ann Rheum Dis. 2015. PMID: 24695009 Free PMC article.
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, Kong A, Gudjonsson SA, Magnusson OT, Masson G; TREAT-OA Consortium; arcOGEN Consortium, Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K. Styrkarsdottir U, et al. Among authors: bomer n. Nat Genet. 2014 May;46(5):498-502. doi: 10.1038/ng.2957. Epub 2014 Apr 13. Nat Genet. 2014. PMID: 24728293
The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.
Bomer N, Cornelis FM, Ramos YF, den Hollander W, Storms L, van der Breggen R, Lakenberg N, Slagboom PE, Meulenbelt I, Lories RJ. Bomer N, et al. Ann Rheum Dis. 2016 Mar;75(3):571-7. doi: 10.1136/annrheumdis-2014-206608. Epub 2014 Dec 30. Ann Rheum Dis. 2016. PMID: 25550340
Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.
den Hollander W, Ramos YF, Bomer N, Elzinga S, van der Breggen R, Lakenberg N, de Dijcker WJ, Suchiman HE, Duijnisveld BJ, Houwing-Duistermaat JJ, Slagboom PE, Bos SD, Nelissen RG, Meulenbelt I. den Hollander W, et al. Among authors: bomer n. Arthritis Rheumatol. 2015 May;67(8):2108-16. doi: 10.1002/art.39162. Arthritis Rheumatol. 2015. PMID: 25892573
Translating genomics into mechanisms of disease: Osteoarthritis.
Bomer N, den Hollander W, Ramos YF, Meulenbelt I. Bomer N, et al. Best Pract Res Clin Rheumatol. 2015 Dec;29(6):683-91. doi: 10.1016/j.berh.2016.01.001. Epub 2016 Mar 4. Best Pract Res Clin Rheumatol. 2015. PMID: 27107506 Review.
Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.
Bomer N, Cornelis FM, Ramos YF, den Hollander W, Lakenberg N, van der Breggen R, Storms L, Slagboom PE, Lories RJ, Meulenbelt I. Bomer N, et al. PLoS One. 2016 May 10;11(5):e0154999. doi: 10.1371/journal.pone.0154999. eCollection 2016. PLoS One. 2016. PMID: 27163789 Free PMC article.
Annotating Transcriptional Effects of Genetic Variants in Disease-Relevant Tissue: Transcriptome-Wide Allelic Imbalance in Osteoarthritic Cartilage.
den Hollander W, Pulyakhina I, Boer C, Bomer N, van der Breggen R, Arindrarto W, Couthino de Almeida R, Lakenberg N, Sentner T, Laros JFJ, 't Hoen PAC, Slagboom EPE, Nelissen RGHH, van Meurs J, Ramos YFM, Meulenbelt I. den Hollander W, et al. Among authors: bomer n. Arthritis Rheumatol. 2019 Apr;71(4):561-570. doi: 10.1002/art.40748. Epub 2019 Feb 23. Arthritis Rheumatol. 2019. PMID: 30298554 Free PMC article.
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