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Page 1
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. Bomfim TR, et al. J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256. J Clin Invest. 2012. PMID: 22476196 Free PMC article.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. Lourenco MV, et al. Among authors: bomfim tr. Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002. Cell Metab. 2013. PMID: 24315369 Free article.
Aβ oligomers induce glutamate release from hippocampal neurons.
Brito-Moreira J, Paula-Lima AC, Bomfim TR, Oliveira FB, Sepúlveda FJ, De Mello FG, Aguayo LG, Panizzutti R, Ferreira ST. Brito-Moreira J, et al. Among authors: bomfim tr. Curr Alzheimer Res. 2011 Aug;8(5):552-62. doi: 10.2174/156720511796391917. Curr Alzheimer Res. 2011. PMID: 21244351
Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity.
Paula-Lima AC, Tricerri MA, Brito-Moreira J, Bomfim TR, Oliveira FF, Magdesian MH, Grinberg LT, Panizzutti R, Ferreira ST. Paula-Lima AC, et al. Among authors: bomfim tr. Int J Biochem Cell Biol. 2009 Jun;41(6):1361-70. doi: 10.1016/j.biocel.2008.12.003. Epub 2008 Dec 14. Int J Biochem Cell Biol. 2009. PMID: 19130896
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Clarke JR, et al. Among authors: bomfim tr. EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183. EMBO Mol Med. 2015. PMID: 25617315 Free PMC article.