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Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis.
Hutchinson C, Geissler CA, Powell JJ, Bomford A. Hutchinson C, et al. Among authors: bomford a. Gut. 2007 Sep;56(9):1291-5. doi: 10.1136/gut.2006.108613. Epub 2007 Mar 7. Gut. 2007. PMID: 17344278 Free PMC article.
RESULTS: There was a significant reduction (p<0.001) in the volume of blood removed annually before (2.5 (0.25) l) and while taking (0.5 (0.25) l) a PPI. ...CONCLUSIONS: Administration of a PPI to patients with HH can inhibit the absorption of non-haem iro …
RESULTS: There was a significant reduction (p<0.001) in the volume of blood removed annually before (2.5 (0.25) l) and while takin …
Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis.
Lombard M, Bomford AB, Polson RJ, Bellingham AJ, Williams R. Lombard M, et al. Among authors: bomford ab. Gastroenterology. 1990 Apr;98(4):976-84. doi: 10.1016/0016-5085(90)90022-s. Gastroenterology. 1990. PMID: 2179037
It is not clear whether this reflects an intrinsic abnormality of iron homeostasis at this site or is a consequence of a more generalized defect in cellular iron metabolism particularly involving the liver. ...Given that body iron stores in both types of iron overlo …
It is not clear whether this reflects an intrinsic abnormality of iron homeostasis at this site or is a consequence of a more …
The association of pretransplant ferritin level with waiting list and post-transplant survival. Does ferritin actually predict outcome?
Al-Freah MA, Kriese S, Foxton MR, Quaglia A, Bomford A, Heaton ND, O'Grady JG, Agarwal K, Wendon JA, Heneghan MA. Al-Freah MA, et al. Among authors: bomford a. Transpl Int. 2013 Nov;26(11):1070-9. doi: 10.1111/tri.12164. Transpl Int. 2013. PMID: 24138201 Free article.
Outcome of liver transplantation in hereditary hemochromatosis.
Dar FS, Faraj W, Zaman MB, Bartlett A, Bomford A, O'Sullivan A, O'Grady J, Heneghan M, Rela M, Heaton ND. Dar FS, et al. Among authors: bomford a. Transpl Int. 2009 Jul;22(7):717-24. doi: 10.1111/j.1432-2277.2009.00863.x. Epub 2009 Mar 16. Transpl Int. 2009. PMID: 19490544
Hereditary hemochromatosis (HH) is a genetic disorder of iron metabolism. It is an uncommon indication for liver transplantation (LT). ...There were seven deaths after a median follow up of 46 months either because of multiorgan failure, or caused by HCC recurrence. …
Hereditary hemochromatosis (HH) is a genetic disorder of iron metabolism. It is an uncommon indication for liver transplantation (LT) …
Genetics of haemochromatosis.
Bomford A. Bomford A. Lancet. 2002 Nov 23;360(9346):1673-81. doi: 10.1016/S0140-6736(02)11607-2. Lancet. 2002. PMID: 12457803 Review.
After identification of the hereditary haemochromatosis gene HFE, and receipt of confirmation that most patients with the condition were homozygous for a single, founder mutation (C282Y), most assumed that C282Y would be a prevalent, highly penetrant mutation in …
After identification of the hereditary haemochromatosis gene HFE, and receipt of confirmation that most patients with the condition were hom …
Post-prandial iron absorption in humans: comparison between HFE genotypes and iron deficiency anaemia.
Hutchinson C, Conway RE, Bomford A, Hider RC, Powell JJ, Geissler CA. Hutchinson C, et al. Among authors: bomford a. Clin Nutr. 2008 Apr;27(2):258-63. doi: 10.1016/j.clnu.2007.12.007. Epub 2008 Feb 13. Clin Nutr. 2008. PMID: 18276042
In five HH patients, using (58)Fe as a tracer, the rate of iron absorption was increased (P<0.05) and serum non-transferrin bound iron showed a tendency to increase (P=0.06). ...CONCLUSIONS: Using the serum iron method we found a comparable increase in pos …
In five HH patients, using (58)Fe as a tracer, the rate of iron absorption was increased (P<0.05) and serum non-transferrin bound …
An iron-regulated ferric reductase associated with the absorption of dietary iron.
McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, Mudaly M, Richardson C, Barlow D, Bomford A, Peters TJ, Raja KB, Shirali S, Hediger MA, Farzaneh F, Simpson RJ. McKie AT, et al. Among authors: bomford a. Science. 2001 Mar 2;291(5509):1755-9. doi: 10.1126/science.1057206. Epub 2001 Feb 1. Science. 2001. PMID: 11230685
The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays adaptive responses to iron status. We have isolated a complementary DNA, Dcytb (for duodenal cytochrome b), which …
The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase act …
Phytohaemagglutinin induced proliferation of lymphocytes from patients with rheumatoid arthritis and iron deficiency.
Polson RJ, Bomford A, Berry H, Williams R. Polson RJ, et al. Among authors: bomford a. Ann Rheum Dis. 1988 Jul;47(7):570-5. doi: 10.1136/ard.47.7.570. Ann Rheum Dis. 1988. PMID: 3401054 Free PMC article.
In addition, iron deficient sera from these patients reduced the PHA induced proliferation of lymphocytes from a normal subject (p less than 0.01), an effect which was prevented by prior addition of iron to these serum samples. In iron containing media lymphocytes from fiv …
In addition, iron deficient sera from these patients reduced the PHA induced proliferation of lymphocytes from a normal subject (p le …
Measurement of ferritin in serum by an indirect competitive enzyme-linked immunosorbant assay.
Polson RJ, Kenna JG, Shears IP, Bomford A, Williams R. Polson RJ, et al. Among authors: bomford a. Clin Chem. 1988 Apr;34(4):661-4. Clin Chem. 1988. PMID: 3359597
Designed for use on microtiter plates, the method has a precision and sensitivity similar to those of other immunoassays. The detection limit is 20 pg of ferritin per test (corresponding to 2.0 micrograms/L in serum samples). Comparison of results obtained on serum from 57 …
Designed for use on microtiter plates, the method has a precision and sensitivity similar to those of other immunoassays. The detecti …
Biochemical studies of the iron cores and polypeptide shells of haemosiderin isolated from patients with primary or secondary haemochromatosis.
Ward RJ, O'Connell MJ, Dickson DP, Reid NM, Wade VJ, Mann S, Bomford A, Peters TJ. Ward RJ, et al. Among authors: bomford a. Biochim Biophys Acta. 1989 Oct 13;993(1):131-3. doi: 10.1016/0304-4165(89)90153-0. Biochim Biophys Acta. 1989. PMID: 2804120
The major peptides separated by SDS-PAGE showed a major band at Mr 20,000 for PHC haemosiderin and at Mr 15,000 for SHC haemosiderin....
The major peptides separated by SDS-PAGE showed a major band at Mr 20,000 for PHC haemosiderin and at Mr 15,000 for SHC haemosiderin. …
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