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Inherited variability of the mitochondrial genome and successful aging in humans.
de Benedictis G, Carrieri G, Varcasia O, Bonafè M, Franceschi C. de Benedictis G, et al. Ann N Y Acad Sci. 2000 Jun;908:208-18. doi: 10.1111/j.1749-6632.2000.tb06648.x. Ann N Y Acad Sci. 2000. PMID: 10911960 Review.
Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging.
Olivieri F, Capri M, Bonafè M, Morsiani C, Jung HJ, Spazzafumo L, Viña J, Suh Y. Olivieri F, et al. Mech Ageing Dev. 2017 Jul;165(Pt B):162-170. doi: 10.1016/j.mad.2016.12.004. Epub 2016 Dec 13. Mech Ageing Dev. 2017. PMID: 27986629 Free PMC article. Review.
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.
Bonafè M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, Mugianesi E, Centurelli M, Franceschi C, Paolisso G. Bonafè M, et al. J Clin Endocrinol Metab. 2003 Jul;88(7):3299-304. doi: 10.1210/jc.2002-021810. J Clin Endocrinol Metab. 2003. PMID: 12843179
An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.
Bonafè M, Barbi C, Olivieri F, Yashin A, Andreev KF, Vaupel JW, De Benedictis G, Rose G, Carrieri G, Jazwinski SM, Franceschi C. Bonafè M, et al. Gene. 2002 Mar 6;286(1):121-6. doi: 10.1016/s0378-1119(01)00812-5. Gene. 2002. PMID: 11943467
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.
Sansone P, Savini C, Kurelac I, Chang Q, Amato LB, Strillacci A, Stepanova A, Iommarini L, Mastroleo C, Daly L, Galkin A, Thakur BK, Soplop N, Uryu K, Hoshino A, Norton L, Bonafé M, Cricca M, Gasparre G, Lyden D, Bromberg J. Sansone P, et al. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9066-E9075. doi: 10.1073/pnas.1704862114. Epub 2017 Oct 11. Proc Natl Acad Sci U S A. 2017. PMID: 29073103 Free PMC article.
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
Bonafè M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C. Bonafè M, et al. Eur J Hum Genet. 2002 May;10(5):292-6. doi: 10.1038/sj.ejhg.5200806. Eur J Hum Genet. 2002. PMID: 12082503
Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. ...We found that the percentage of carriers of the B allele at codon 192 (B …
Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutam …
In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.
Olivieri F, Bonafè M, Giovagnetti S, Stecconi R, Cardelli M, Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C, Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S, Franceschi C. Olivieri F, et al. Mech Ageing Dev. 2003 Apr;124(4):549-53. doi: 10.1016/s0047-6374(03)00035-6. Mech Ageing Dev. 2003. PMID: 12714266
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.
Zhang J, Asin-Cayuela J, Fish J, Michikawa Y, Bonafe M, Olivieri F, Passarino G, De Benedictis G, Franceschi C, Attardi G. Zhang J, et al. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1116-21. doi: 10.1073/pnas.242719399. Epub 2003 Jan 21. Proc Natl Acad Sci U S A. 2003. PMID: 12538859 Free PMC article.
The role of IL-1 gene cluster in longevity: a study in Italian population.
Cavallone L, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Giovagnetti S, Di Stasio G, Giampieri C, Mugianesi E, Stecconi R, Sciacca F, Grimaldi LM, De Benedictis G, Lio D, Caruso C, Franceschi C. Cavallone L, et al. Mech Ageing Dev. 2003 Apr;124(4):533-8. doi: 10.1016/s0047-6374(03)00033-2. Mech Ageing Dev. 2003. PMID: 12714264
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