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Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections.
Bertoletti A, et al. Gastroenterology 1997. Among authors: Boni C. PMID 8978359
BACKGROUND & AIMS: The cytokine pattern secreted by T cells at the site of viral replication may influence the final outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. The aim of this study was to assess whether a cytokine imbalance oriented toward T helper (Th) 1 or Th2-type responses may play a role in chronic hepatitis B or C. ...
BACKGROUND & AIMS: The cytokine pattern secreted by T cells at the site of viral replication may influence the final outcome of hepatiti …
Antiviral cell-mediated immune responses during hepatitis B and hepatitis C virus infections.
Ferrari C, et al. Recent Results Cancer Res 1998 - Review. Among authors: Boni C. PMID 10027013
Cell-mediated immune responses to hepatitis B (HBV) and hepatitis C virus (HCV) antigens are vigorous and multispecific in acute, self-limited infections. ...This is shown by the finding that HCV-specific CD4- and CD8-mediated responses are easily detectable in the peripheral blood of patients with long-lasting chronic hepatitis C and that production of Th1 cytokines predominates within their livers. ...
Cell-mediated immune responses to hepatitis B (HBV) and hepatitis C virus (HCV) antigens are vigorous and multispecific in acute, sel …
Conserved hepatitis C virus sequences are highly immunogenic for CD4(+) T cells: implications for vaccine development.
Lamonaca V, et al. Hepatology 1999. Among authors: Boni C. PMID 10498664
The HLA class II-restricted T-cell response to hepatitis C virus (HCV) antigens is believed to influence the final outcome of hepatitis C, because it is vigorous in patients who recover from acute hepatitis C, but it is weak in those who develop a chronic infection. For this reason, exogenous stimulation of T-cell responses in chronic HCV infection may represent a strategy to cure patients with chronic hepatitis C by approximating the vigor of their T-cell reactivity to that of patients who succeed in recovering from hepatitis. ...
The HLA class II-restricted T-cell response to hepatitis C virus (HCV) antigens is believed to influence the final outcome of hepatit …
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