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Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.
Almeida L, Rocha JF, Falcão A, Palma PN, Loureiro AI, Pinto R, Bonifácio MJ, Wright LC, Nunes T, Soares-da-Silva P. Almeida L, et al. Among authors: bonifacio mj. Clin Pharmacokinet. 2013 Feb;52(2):139-51. doi: 10.1007/s40262-012-0024-7. Clin Pharmacokinet. 2013. PMID: 23248072 Clinical Trial.
Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects.
Rocha JF, Almeida L, Falcão A, Palma PN, Loureiro AI, Pinto R, Bonifácio MJ, Wright LC, Nunes T, Soares-da-Silva P. Rocha JF, et al. Among authors: bonifacio mj. Br J Clin Pharmacol. 2013 Nov;76(5):763-75. doi: 10.1111/bcp.12081. Br J Clin Pharmacol. 2013. PMID: 23336248 Free PMC article. Clinical Trial.
Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.
Rocha JF, Sicard É, Fauchoux N, Falcão A, Santos A, Loureiro AI, Pinto R, Bonifácio MJ, Nunes T, Almeida L, Soares-da-Silva P. Rocha JF, et al. Among authors: bonifacio mj. Br J Clin Pharmacol. 2017 Mar;83(3):540-553. doi: 10.1111/bcp.13156. Epub 2016 Dec 2. Br J Clin Pharmacol. 2017. PMID: 27763682 Free PMC article. Clinical Trial.
Absorption, metabolism and excretion of opicapone in human healthy volunteers.
Loureiro AI, Rocha F, Santos AT, Singh N, Bonifácio MJ, Pinto R, Kiss LE, Soares-da-Silva P. Loureiro AI, et al. Among authors: bonifacio mj. Br J Clin Pharmacol. 2022 Oct;88(10):4540-4551. doi: 10.1111/bcp.15383. Epub 2022 May 20. Br J Clin Pharmacol. 2022. PMID: 35508762 Free PMC article.
63 results