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Immunology of hepatitis C virus infections.
Spaan M, Janssen HL, Boonstra A. Spaan M, et al. Best Pract Res Clin Gastroenterol. 2012 Aug;26(4):391-400. doi: 10.1016/j.bpg.2012.09.005. Best Pract Res Clin Gastroenterol. 2012. PMID: 23199499 Review.
The immune response in patients chronically infected with HCV plays a unique role during the infection because of its potential to contribute not only to viral clearance and, in some cases, protective immunity, but also to liver injury. A detailed understanding of t …
The immune response in patients chronically infected with HCV plays a unique role during the infection because of its potential to co …
Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients.
Stoop JN, Claassen MA, Woltman AM, Binda RS, Kuipers EJ, Janssen HL, van der Molen RG, Boonstra A. Stoop JN, et al. Clin Immunol. 2008 Dec;129(3):419-27. doi: 10.1016/j.clim.2008.07.029. Epub 2008 Sep 26. Clin Immunol. 2008. PMID: 18823821
In this study, we examined the phenotype of FoxP3+ regulatory T cells in the liver of patients with a chronic HBV infection. ...Patients with a high viral load have a higher proportion of regulatory T cells in the liver, but not in blood, compared to patients …
In this study, we examined the phenotype of FoxP3+ regulatory T cells in the liver of patients with a chronic HBV infection. ...Patie …
Immunology of hepatitis B and hepatitis C virus infections.
Boonstra A, Woltman AM, Janssen HL. Boonstra A, et al. Best Pract Res Clin Gastroenterol. 2008;22(6):1049-61. doi: 10.1016/j.bpg.2008.11.015. Best Pract Res Clin Gastroenterol. 2008. PMID: 19187866 Review.
Experimental models for hepatitis C viral infection.
Boonstra A, van der Laan LJ, Vanwolleghem T, Janssen HL. Boonstra A, et al. Hepatology. 2009 Nov;50(5):1646-55. doi: 10.1002/hep.23138. Hepatology. 2009. PMID: 19670425 Review.
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease. The majority of infected individuals develop a persistent infection, which is associated with a high risk of liver cirrhosis and hepatocellular carcinoma. ...These systems have mad …
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease. The majority of infected individuals develop a
Alpha-galactosylceramide in chronic hepatitis B infection: results from a randomized placebo-controlled Phase I/II trial.
Woltman AM, Ter Borg MJ, Binda RS, Sprengers D, von Blomberg BM, Scheper RJ, Hayashi K, Nishi N, Boonstra A, van der Molen R, Janssen HL. Woltman AM, et al. Antivir Ther. 2009;14(6):809-18. doi: 10.3851/IMP1295. Antivir Ther. 2009. PMID: 19812443 Clinical Trial.
RESULTS: Almost all alpha-GalCer-treated patients showed a rapid and strong decrease in natural killer T-cell (NKT) numbers. ...Three patients demonstrated a transient decrease in hepatitis B virus (HBV) DNA. Only one alpha-GalCer-treated patient had a sustai …
RESULTS: Almost all alpha-GalCer-treated patients showed a rapid and strong decrease in natural killer T-cell (NKT) numbers. ...Three …
Dendritic cells in chronic viral hepatitis B and C: victims or guardian angels?
Woltman AM, Boonstra A, Janssen HL. Woltman AM, et al. Gut. 2010 Jan;59(1):115-25. doi: 10.1136/gut.2009.181040. Gut. 2010. PMID: 20007959 Review. No abstract available.
Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis.
Claassen MA, de Knegt RJ, Tilanus HW, Janssen HL, Boonstra A. Claassen MA, et al. J Hepatol. 2010 Mar;52(3):315-21. doi: 10.1016/j.jhep.2009.12.013. Epub 2009 Dec 24. J Hepatol. 2010. PMID: 20129690
Moreover, in all patients, intrahepatic CD4+FoxP3+ Treg showed a fully differentiated and highly activated phenotype on the basis of the surface markers CD45RO, CCR7, CTLA-4 and HLA-DR. ...This suggests that CD4+FoxP3+ Treg play a pivotal role in limiting collateral …
Moreover, in all patients, intrahepatic CD4+FoxP3+ Treg showed a fully differentiated and highly activated phenotype on the basis of …
IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNγ receptor expression.
Liu BS, Janssen HL, Boonstra A. Liu BS, et al. Blood. 2011 Feb 24;117(8):2385-95. doi: 10.1182/blood-2010-07-298976. Epub 2010 Dec 29. Blood. 2011. PMID: 21190998
Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections.
Liu BS, Groothuismink ZM, Janssen HL, Boonstra A. Liu BS, et al. J Leukoc Biol. 2011 Jun;89(6):981-8. doi: 10.1189/jlb.1210680. Epub 2011 Mar 8. J Leukoc Biol. 2011. PMID: 21385948
This suggests that there is no overall increased susceptibility to pathogens but a specific suppression of the functionality of TLR4 signaling pathway in monocytes, which is, at least partly, mediated via IL-10....
This suggests that there is no overall increased susceptibility to pathogens but a specific suppression of the functionality of TLR4 …
Retention of CD4+ CD25+ FoxP3+ regulatory T cells in the liver after therapy-induced hepatitis C virus eradication in humans.
Claassen MA, de Knegt RJ, Janssen HL, Boonstra A. Claassen MA, et al. J Virol. 2011 Jun;85(11):5323-30. doi: 10.1128/JVI.02551-10. Epub 2011 Mar 30. J Virol. 2011. PMID: 21450832 Free PMC article.
The phenotype of those Treg that were retained in the liver months after therapy-induced clearance of HCV RNA indicated a reduced contribution of effector memory cells. ...The continuous presence of high numbers of Treg, with a phenotype reflecting a relative …
The phenotype of those Treg that were retained in the liver months after therapy-induced clearance of HCV RNA indicated a reduced con …
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