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Novel ligands for the human histamine H1 receptor: synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes.
Ghoneim OM, Legere JA, Golbraikh A, Tropsha A, Booth RG. Ghoneim OM, et al. Bioorg Med Chem. 2006 Oct 1;14(19):6640-58. doi: 10.1016/j.bmc.2006.05.077. Epub 2006 Jun 16. Bioorg Med Chem. 2006. PMID: 16782354
Ligand-directed functional heterogeneity of histamine H1 receptors: novel dual-function ligands selectively activate and block H1-mediated phospholipase C and adenylyl cyclase signaling.
Moniri NH, Covington-Strachan D, Booth RG. Moniri NH, et al. J Pharmacol Exp Ther. 2004 Oct;311(1):274-81. doi: 10.1124/jpet.104.070086. Epub 2004 May 28. J Pharmacol Exp Ther. 2004. PMID: 15169829
Domain swapping in the human histamine H1 receptor.
Bakker RA, Dees G, Carrillo JJ, Booth RG, López-Gimenez JF, Milligan G, Strange PG, Leurs R. Bakker RA, et al. J Pharmacol Exp Ther. 2004 Oct;311(1):131-8. doi: 10.1124/jpet.104.067041. Epub 2004 May 24. J Pharmacol Exp Ther. 2004. PMID: 15159444
Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
Mottola DM, Kilts JD, Lewis MM, Connery HS, Walker QD, Jones SR, Booth RG, Hyslop DK, Piercey M, Wightman RM, Lawler CP, Nichols DE, Mailman RB. Mottola DM, et al. J Pharmacol Exp Ther. 2002 Jun;301(3):1166-78. doi: 10.1124/jpet.301.3.1166. J Pharmacol Exp Ther. 2002. PMID: 12023552
A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.
Booth RG, Moniri NH, Bakker RA, Choksi NY, Nix WB, Timmerman H, Leurs R. Booth RG, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):328-36. doi: 10.1124/jpet.302.1.328. J Pharmacol Exp Ther. 2002. PMID: 12065734
(1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity.
Booth RG, Fang L, Huang Y, Wilczynski A, Sivendran S. Booth RG, et al. Eur J Pharmacol. 2009 Aug 1;615(1-3):1-9. doi: 10.1016/j.ejphar.2009.04.035. Epub 2009 May 3. Eur J Pharmacol. 2009. PMID: 19397907 Free PMC article.
Molecular determinants of ligand-directed signaling for the histamine H1 receptor.
Booth RG, Fang L, Wilczynski A, Sivendren S, Sun Z, Travers S, Bruysters M, Sansuk K, Leurs R. Booth RG, et al. Inflamm Res. 2008;57 Suppl 1(0 1):S43-4. doi: 10.1007/s00011-007-0621-3. Inflamm Res. 2008. PMID: 18345497 Free PMC article. No abstract available.
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