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Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond.
Artursson P, Borchardt RT. Artursson P, et al. Among authors: borchardt rt. Pharm Res. 1997 Dec;14(12):1655-8. doi: 10.1023/a:1012155124489. Pharm Res. 1997. PMID: 9453050 Review. No abstract available.
Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa.
Nofsinger R, Borchardt RT. Nofsinger R, et al. Among authors: borchardt rt. J Pharm Sci. 2012 Sep;101(9):3500-10. doi: 10.1002/jps.23079. Epub 2012 Feb 15. J Pharm Sci. 2012. PMID: 22337204
A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum.
Johnson BM, Chen W, Borchardt RT, Charman WN, Porter CJ. Johnson BM, et al. Among authors: borchardt rt. J Pharmacol Exp Ther. 2003 Apr;305(1):151-8. doi: 10.1124/jpet.102.045328. J Pharmacol Exp Ther. 2003. PMID: 12649363
Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism.
Mudra DR, Borchardt RT. Mudra DR, et al. Among authors: borchardt rt. J Pharm Sci. 2010 Feb;99(2):1016-27. doi: 10.1002/jps.21836. J Pharm Sci. 2010. PMID: 19650119
A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.
Ouyang H, Tang F, Siahaan TJ, Borchardt RT. Ouyang H, et al. Among authors: borchardt rt. Pharm Res. 2002 Jun;19(6):794-801. doi: 10.1023/a:1016148631055. Pharm Res. 2002. PMID: 12134949
Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism.
Mudra DR, Jin JY, Borchardt RT. Mudra DR, et al. Among authors: borchardt rt. J Pharm Sci. 2010 Feb;99(2):999-1015. doi: 10.1002/jps.21965. J Pharm Sci. 2010. PMID: 19798765
Absorption barriers in the rat intestinal mucosa: 1. Application of an in situ perfusion model to simultaneously assess drug permeation and metabolism.
Mudra DR, Borchardt RT. Mudra DR, et al. Among authors: borchardt rt. J Pharm Sci. 2010 Feb;99(2):982-98. doi: 10.1002/jps.21912. J Pharm Sci. 2010. PMID: 19746412
Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa.
Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT. Ouyang H, et al. Among authors: borchardt rt. J Pharm Sci. 2009 Jan;98(1):349-61. doi: 10.1002/jps.21424. J Pharm Sci. 2009. PMID: 18537150
Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.
Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT. Ouyang H, et al. Among authors: borchardt rt. J Pharm Sci. 2009 Jan;98(1):337-48. doi: 10.1002/jps.21428. J Pharm Sci. 2009. PMID: 18537149
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.
Horie K, Tang F, Borchardt RT. Horie K, et al. Among authors: borchardt rt. Pharm Res. 2003 Feb;20(2):161-8. doi: 10.1023/a:1022359300826. Pharm Res. 2003. PMID: 12636153
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