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To automate or not to automate: this is the question.
Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W. Cymborowski M, et al. Among authors: borek d. J Struct Funct Genomics. 2010 Sep;11(3):211-21. doi: 10.1007/s10969-010-9092-9. Epub 2010 Jun 6. J Struct Funct Genomics. 2010. PMID: 20526815 Free PMC article.
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK. Leung DW, et al. Nat Struct Mol Biol. 2010 Feb;17(2):165-72. doi: 10.1038/nsmb.1765. Epub 2010 Jan 17. Nat Struct Mol Biol. 2010. PMID: 20081868 Free PMC article.
Structure and mechanism of a eukaryotic FMN adenylyltransferase.
Huerta C, Borek D, Machius M, Grishin NV, Zhang H. Huerta C, et al. Among authors: borek d. J Mol Biol. 2009 Jun 5;389(2):388-400. doi: 10.1016/j.jmb.2009.04.022. Epub 2009 Apr 16. J Mol Biol. 2009. PMID: 19375431 Free PMC article.
Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.
Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK. Leung DW, et al. Among authors: borek d. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):689-92. doi: 10.1107/S1744309110013266. Epub 2010 May 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20516601 Free PMC article.
In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK. Brown CS, et al. J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1. J Mol Biol. 2014. PMID: 24495995 Free PMC article.
84 results