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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
Gunasekaran K, Pentony M, Shen M, Garrett L, Forte C, Woodward A, Ng SB, Born T, Retter M, Manchulenko K, Sweet H, Foltz IN, Wittekind M, Yan W. Gunasekaran K, et al. Among authors: Born T. J Biol Chem. 2010 Jun 18;285(25):19637-46. doi: 10.1074/jbc.M110.117382. Epub 2010 Apr 16. J Biol Chem. 2010. PMID: 20400508 Free PMC article.
Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.
Born TL, Smith DE, Garka KE, Renshaw BR, Bertles JS, Sims JE. Born TL, et al. J Biol Chem. 2000 Sep 29;275(39):29946-54. doi: 10.1074/jbc.M004077200. J Biol Chem. 2000. PMID: 10882729
., Bienvenu, T., Vinet, M. C., McDonell, N., Couvert, P., Zemni, R., Cardona, A., Van Buggenhout, G., Frints, S., Hamel, B., Moraine, C., Ropers, H. H., Strom, T., Howell, G. R., Whittaker, A., Ross, M. T., Kahn, A., Fryns, J. P., Beldjord, C., Marynen, P., and Chelly, J. (1999) Nat. ...
., Bienvenu, T., Vinet, M. C., McDonell, N., Couvert, P., Zemni, R., Cardona, A., Van Buggenhout, G., Frints, S., Hamel, B., Moraine, …
Positive regulation of cdc2 gene activity by protein phosphatase type 2A.
Jaramillo-Babb VL, Sugarmans JL, Scavetta R, Wang SJ, Berndt N, Born TL, Glass CK, Schönthal AH. Jaramillo-Babb VL, et al. Among authors: Born TL. J Biol Chem. 1996 Mar 15;271(11):5988-92. doi: 10.1074/jbc.271.11.5988. J Biol Chem. 1996. PMID: 8626381
Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage.
Sivakumar PV, Westrich GM, Kanaly S, Garka K, Born TL, Derry JM, Viney JL. Sivakumar PV, et al. Among authors: Born TL. Gut. 2002 Jun;50(6):812-20. doi: 10.1136/gut.50.6.812. Gut. 2002. PMID: 12010883 Free PMC article.
Cytokines play an important role in immune regulation and interleukin 18 (IL-18) is one such cytokine that has emerged as being instrumental in driving CD4+ T cell responses towards a Th1-type. IL-18 can also directly mediate inflammation, moderate interleukin 1 activity, and can act on cell types other than T cells. ...
Cytokines play an important role in immune regulation and interleukin 18 (IL-18) is one such cytokine that has emerged as being instrumental …
4-(Fluoromethyl)phenyl phosphate acts as a mechanism-based inhibitor of calcineurin.
Born TL, Myers JK, Widlanski TS, Rusnak F. Born TL, et al. J Biol Chem. 1995 Oct 27;270(43):25651-5. doi: 10.1074/jbc.270.43.25651. J Biol Chem. 1995. PMID: 7592741
., and Widlanski, T.S. (1993) Science 262, 1451-1453), was examined for its effect on calcineurin. This compound inhibits calcineurin in a time-dependent, first order manner. ...
., and Widlanski, T.S. (1993) Science 262, 1451-1453), was examined for its effect on calcineurin. This compound inhibits calcineurin …
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