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mRNA transcript distribution bias between Borrelia burgdorferi bacteria and their outer membrane vesicles.
Malge A, Ghai V, Reddy PJ, Baxter D, Kim TK, Moritz RL, Wang K. Malge A, et al. FEMS Microbiol Lett. 2018 Jul 1;365(13):fny135. doi: 10.1093/femsle/fny135. FEMS Microbiol Lett. 2018. PMID: 29846577 Free PMC article.
Borrelia burgdorferi, a bacterium in the spirochete phylum, is the causative agent of Lyme disease. Borrelia burgdorferi has a linear chromosome with a number of circular and linear plasmids. ...
Borrelia burgdorferi, a bacterium in the spirochete phylum, is the causative agent of Lyme disease. Borrelia burgdorferi has a
Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis.
Klouwens MJ, Salverda MLM, Trentelman JJ, Ersoz JI, Wagemakers A, Gerritzen MJH, van der Ley PA, Hovius JW. Klouwens MJ, et al. Vaccine. 2021 Apr 28;39(18):2561-2567. doi: 10.1016/j.vaccine.2021.03.059. Epub 2021 Apr 1. Vaccine. 2021. PMID: 33812741 Free article.
The expression of recombinant antigens in meningococcal Outer Membrane Vesicles (OMVs), with the OMV functioning both as adjuvant and delivery vehicle, greatly enhances their potential. ...Finally, qPCR and culture data show that both the OspA-OMV and the vaccine based on …
The expression of recombinant antigens in meningococcal Outer Membrane Vesicles (OMVs), with the OMV functioning both as adjuvant and …
Protein Secretion in Spirochetes.
Zückert WR. Zückert WR. Microbiol Spectr. 2019 May;7(3):10.1128/microbiolspec.PSIB-0026-2019. doi: 10.1128/microbiolspec.PSIB-0026-2019. Microbiol Spectr. 2019. PMID: 31198130 Free PMC article.
Leptospira most closely track Gram-negative bacteria due to the incorporation of lipopolysaccharides. Treponema and Borrelia outer membranes lack lipopolysaccharide, with treponemes expressing only a few outer membrane proteins and Borrelia displaying a dizzying div …
Leptospira most closely track Gram-negative bacteria due to the incorporation of lipopolysaccharides. Treponema and Borrelia outer me …
Purification of Borrelia burgdorferi Outer Membrane Vesicles.
Tammisto H, Karvonen K. Tammisto H, et al. Methods Mol Biol. 2024;2742:37-45. doi: 10.1007/978-1-0716-3561-2_3. Methods Mol Biol. 2024. PMID: 38165613
Bacterial outer membrane vesicles (OMVs) are spherical membrane constructs shed by gram-negative bacteria. OMVs produced by the Lyme disease pathogen Borrelia burgdorferi have been identified to contain such virulence factors as OspA, OspB, OspC, and genetic materia …
Bacterial outer membrane vesicles (OMVs) are spherical membrane constructs shed by gram-negative bacteria. OMVs produced by the Lyme …
An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling.
Petnicki-Ocwieja T, Sharma B, Powale U, Pathak D, Tan S, Hu LT. Petnicki-Ocwieja T, et al. Traffic. 2022 Dec;23(12):558-567. doi: 10.1111/tra.12870. Epub 2022 Oct 24. Traffic. 2022. PMID: 36224049 Free PMC article.
We identified Rab8 and Rab11 GTPases as important in IL-6 induction upon stimulation with the TLR2 ligand Pam(3) CSK(4) or the pathogen, Borrelia burgdorferi (Bb), the causative agent of Lyme disease. These Rabs were recruited to late and lysosomal stage phagosomes and co- …
We identified Rab8 and Rab11 GTPases as important in IL-6 induction upon stimulation with the TLR2 ligand Pam(3) CSK(4) or the pathogen, …
Borrelia burgdorferi Outer Membrane Vesicles Contain Antigenic Proteins, but Do Not Induce Cell Death in Human Cells.
Karvonen K, Tammisto H, Nykky J, Gilbert L. Karvonen K, et al. Microorganisms. 2022 Jan 19;10(2):212. doi: 10.3390/microorganisms10020212. Microorganisms. 2022. PMID: 35208666 Free PMC article.
Like many bacterial species, Borrelia burgdorferi, the pleomorphic bacterium that causes Lyme borreliosis, produces outer membrane vesicles (OMVs). ...In addition, BbOMVs were cocultured with human non-immune cells for cytotoxicity analysis. The results demonstrated …
Like many bacterial species, Borrelia burgdorferi, the pleomorphic bacterium that causes Lyme borreliosis, produces outer membrane …
Lipid exchange between Borrelia burgdorferi and host cells.
Crowley JT, Toledo AM, LaRocca TJ, Coleman JL, London E, Benach JL. Crowley JT, et al. PLoS Pathog. 2013 Jan;9(1):e1003109. doi: 10.1371/journal.ppat.1003109. Epub 2013 Jan 10. PLoS Pathog. 2013. PMID: 23326230 Free PMC article.
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. ...The transfer occurs through two diff
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness
Effect of Borrelia burgdorferi Outer Membrane Vesicles on Host Oxidative Stress Response.
Wawrzeniak K, Gaur G, Sapi E, Senejani AG. Wawrzeniak K, et al. Antibiotics (Basel). 2020 May 25;9(5):275. doi: 10.3390/antibiotics9050275. Antibiotics (Basel). 2020. PMID: 32466166 Free PMC article.
Outer membrane vesicles (OMVs) are spherical bodies containing proteins and nucleic acids that are released by Gram-negative bacteria, including Borrelia burgdorferi, the causative agent of Lyme disease. ...
Outer membrane vesicles (OMVs) are spherical bodies containing proteins and nucleic acids that are released by Gram-negative bacteria …
ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages.
Naj X, Linder S. Naj X, et al. Cell Rep. 2015 Sep 22;12(11):1816-30. doi: 10.1016/j.celrep.2015.08.027. Epub 2015 Sep 3. Cell Rep. 2015. PMID: 26344766 Free article.
We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes that are in close contact with Rab5a-positive vesicles. Compaction of borreliae involves membrane extrusion from phagosomes, …
We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes …
Comparison of protection in rabbits against host-adapted and cultivated Borrelia burgdorferi following infection-derived immunity or immunization with outer membrane vesicles or outer surface protein A.
Shang ES, Champion CI, Wu XY, Skare JT, Blanco DR, Miller JN, Lovett MA. Shang ES, et al. Infect Immun. 2000 Jul;68(7):4189-99. doi: 10.1128/IAI.68.7.4189-4199.2000. Infect Immun. 2000. PMID: 10858236 Free PMC article.
In this study, infection-derived immunity in the rabbit model of Lyme disease was compared to immunity following immunization with purified outer membrane vesicles (OMV) isolated from Borrelia burgdorferi and recombinant outer surface protein A (OspA). ...
In this study, infection-derived immunity in the rabbit model of Lyme disease was compared to immunity following immunization with purified …
56 results