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Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis.
Klouwens MJ, Salverda MLM, Trentelman JJ, Ersoz JI, Wagemakers A, Gerritzen MJH, van der Ley PA, Hovius JW. Klouwens MJ, et al. Vaccine. 2021 Apr 28;39(18):2561-2567. doi: 10.1016/j.vaccine.2021.03.059. Epub 2021 Apr 1. Vaccine. 2021. PMID: 33812741 Free article.
The expression of recombinant antigens in meningococcal Outer Membrane Vesicles (OMVs), with the OMV functioning both as adjuvant and delivery vehicle, greatly enhances their potential. ...Finally, qPCR and culture data show that both the OspA-OMV and the vaccine based on …
The expression of recombinant antigens in meningococcal Outer Membrane Vesicles (OMVs), with the OMV functioning both as adjuvant and …
mRNA transcript distribution bias between Borrelia burgdorferi bacteria and their outer membrane vesicles.
Malge A, Ghai V, Reddy PJ, Baxter D, Kim TK, Moritz RL, Wang K. Malge A, et al. FEMS Microbiol Lett. 2018 Jul 1;365(13):fny135. doi: 10.1093/femsle/fny135. FEMS Microbiol Lett. 2018. PMID: 29846577 Free PMC article.
Borrelia burgdorferi, a bacterium in the spirochete phylum, is the causative agent of Lyme disease. Borrelia burgdorferi has a linear chromosome with a number of circular and linear plasmids. ...
Borrelia burgdorferi, a bacterium in the spirochete phylum, is the causative agent of Lyme disease. Borrelia burgdorferi has a
Effect of Borrelia burgdorferi Outer Membrane Vesicles on Host Oxidative Stress Response.
Wawrzeniak K, Gaur G, Sapi E, Senejani AG. Wawrzeniak K, et al. Antibiotics (Basel). 2020 May 25;9(5):275. doi: 10.3390/antibiotics9050275. Antibiotics (Basel). 2020. PMID: 32466166 Free PMC article.
Outer membrane vesicles (OMVs) are spherical bodies containing proteins and nucleic acids that are released by Gram-negative bacteria, including Borrelia burgdorferi, the causative agent of Lyme disease. ...
Outer membrane vesicles (OMVs) are spherical bodies containing proteins and nucleic acids that are released by Gram-negative bacteria …
Lipid exchange between Borrelia burgdorferi and host cells.
Crowley JT, Toledo AM, LaRocca TJ, Coleman JL, London E, Benach JL. Crowley JT, et al. PLoS Pathog. 2013 Jan;9(1):e1003109. doi: 10.1371/journal.ppat.1003109. Epub 2013 Jan 10. PLoS Pathog. 2013. PMID: 23326230 Free PMC article.
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. ...The transfer occurs through two diff
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness
Protein Secretion in Spirochetes.
Zückert WR. Zückert WR. Microbiol Spectr. 2019 May;7(3):10.1128/microbiolspec.PSIB-0026-2019. doi: 10.1128/microbiolspec.PSIB-0026-2019. Microbiol Spectr. 2019. PMID: 31198130 Free PMC article.
Leptospira most closely track Gram-negative bacteria due to the incorporation of lipopolysaccharides. Treponema and Borrelia outer membranes lack lipopolysaccharide, with treponemes expressing only a few outer membrane proteins and Borrelia displaying a dizzying div …
Leptospira most closely track Gram-negative bacteria due to the incorporation of lipopolysaccharides. Treponema and Borrelia outer me …
ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages.
Naj X, Linder S. Naj X, et al. Cell Rep. 2015 Sep 22;12(11):1816-30. doi: 10.1016/j.celrep.2015.08.027. Epub 2015 Sep 3. Cell Rep. 2015. PMID: 26344766 Free article.
We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes that are in close contact with Rab5a-positive vesicles. Compaction of borreliae involves membrane extrusion from phagosomes, …
We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes …
SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9.
Klose M, Salloum JE, Gonschior H, Linder S. Klose M, et al. J Cell Biol. 2019 Sep 2;218(9):3039-3059. doi: 10.1083/jcb.201812106. Epub 2019 Jul 23. J Cell Biol. 2019. PMID: 31337623 Free PMC article.
The spirochete Borrelia burgdorferi, the causative agent of Lyme disease, is internalized by macrophages and processed in phagolysosomes. Phagosomal compaction, a crucial step in phagolysosome maturation, is driven by contact of Rab5a-positive vesicles with the phag …
The spirochete Borrelia burgdorferi, the causative agent of Lyme disease, is internalized by macrophages and processed in phagolysoso …
Extrachromosomal elements of spirochetes.
Bergström S, Garon CF, Barbour AG, MacDougall J. Bergström S, et al. Res Microbiol. 1992 Jul-Aug;143(6):623-8. doi: 10.1016/0923-2508(92)90120-d. Res Microbiol. 1992. PMID: 1475522 Review.
The spirochetes include some important pathogenic bacteria, Treponema, Borrelia and Leptospira. The pathogeneses of these spirochetes are very diverse. ...Moreover, the molecular analysis of the terminal ends of one of the linear minichromosomes has revealed that this uniq …
The spirochetes include some important pathogenic bacteria, Treponema, Borrelia and Leptospira. The pathogeneses of these spirochetes …
Spontaneously released Neisseria meningitidis outer membrane vesicles as vaccine platform: production and purification.
Gerritzen MJH, Salverda MLM, Martens DE, Wijffels RH, Stork M. Gerritzen MJH, et al. Vaccine. 2019 Nov 8;37(47):6978-6986. doi: 10.1016/j.vaccine.2019.01.076. Epub 2019 Aug 2. Vaccine. 2019. PMID: 31383485 Free article.
Outer membrane vesicles (OMVs) are nanoparticles produced by Gram-negative bacteria that can be used as vaccines. ...This study aims to develop a production process for such OMV-based vaccines and studies a production method based on meningococcal OMVs that express heterol …
Outer membrane vesicles (OMVs) are nanoparticles produced by Gram-negative bacteria that can be used as vaccines. ...This study aims …
Borrelia burgdorferi Outer Membrane Vesicles Contain Antigenic Proteins, but Do Not Induce Cell Death in Human Cells.
Karvonen K, Tammisto H, Nykky J, Gilbert L. Karvonen K, et al. Microorganisms. 2022 Jan 19;10(2):212. doi: 10.3390/microorganisms10020212. Microorganisms. 2022. PMID: 35208666 Free PMC article.
Like many bacterial species, Borrelia burgdorferi, the pleomorphic bacterium that causes Lyme borreliosis, produces outer membrane vesicles (OMVs). ...In addition, BbOMVs were cocultured with human non-immune cells for cytotoxicity analysis. The results demonstrated …
Like many bacterial species, Borrelia burgdorferi, the pleomorphic bacterium that causes Lyme borreliosis, produces outer membrane …
51 results