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Page 1
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.
Boslem E, Meikle PJ, Biden TJ. Boslem E, et al. Islets. 2012 May-Jun;4(3):177-87. doi: 10.4161/isl.20102. Islets. 2012. PMID: 22847494 Free PMC article. Review.
Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass.
Cantley J, Davenport A, Vetterli L, Nemes NJ, Whitworth PT, Boslem E, Thai LM, Mellett N, Meikle PJ, Hoehn KL, James DE, Biden TJ. Cantley J, et al. Among authors: boslem e. Diabetologia. 2019 Jan;62(1):99-111. doi: 10.1007/s00125-018-4743-7. Epub 2018 Oct 17. Diabetologia. 2019. PMID: 30334081 Free PMC article.
A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens.
Pearson GL, Mellett N, Chu KY, Boslem E, Meikle PJ, Biden TJ. Pearson GL, et al. Among authors: boslem e. Mol Metab. 2016 Apr 13;5(6):404-414. doi: 10.1016/j.molmet.2016.04.003. eCollection 2016 Jun. Mol Metab. 2016. PMID: 27257600 Free PMC article.
Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.
Biden TJ, Boslem E, Chu KY, Sue N. Biden TJ, et al. Among authors: boslem e. Trends Endocrinol Metab. 2014 Aug;25(8):389-98. doi: 10.1016/j.tem.2014.02.003. Epub 2014 Mar 18. Trends Endocrinol Metab. 2014. PMID: 24656915 Review.
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells.
Boslem E, Weir JM, MacIntosh G, Sue N, Cantley J, Meikle PJ, Biden TJ. Boslem E, et al. J Biol Chem. 2013 Sep 13;288(37):26569-82. doi: 10.1074/jbc.M113.489310. Epub 2013 Jul 29. J Biol Chem. 2013. PMID: 23897822 Free PMC article.
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
Boslem E, MacIntosh G, Preston AM, Bartley C, Busch AK, Fuller M, Laybutt DR, Meikle PJ, Biden TJ. Boslem E, et al. Biochem J. 2011 Apr 1;435(1):267-76. doi: 10.1042/BJ20101867. Biochem J. 2011. PMID: 21265737
Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.
Cantley J, Boslem E, Laybutt DR, Cordery DV, Pearson G, Carpenter L, Leitges M, Biden TJ. Cantley J, et al. Among authors: boslem e. Diabetologia. 2011 Feb;54(2):380-9. doi: 10.1007/s00125-010-1962-y. Epub 2010 Nov 20. Diabetologia. 2011. PMID: 21103982
Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.
McCloy RA, Shelley EJ, Roberts CG, Boslem E, Biden TJ, Nicholson RI, Gee JM, Sutherland RL, Musgrove EA, Burgess A, Butt AJ. McCloy RA, et al. Among authors: boslem e. Br J Cancer. 2013 Dec 10;109(12):3034-41. doi: 10.1038/bjc.2013.693. Epub 2013 Oct 31. Br J Cancer. 2013. PMID: 24178758 Free PMC article.
Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease.
Smeuninx B, Boslem E, Febbraio MA. Smeuninx B, et al. Among authors: boslem e. Cancers (Basel). 2020 Jun 28;12(7):1714. doi: 10.3390/cancers12071714. Cancers (Basel). 2020. PMID: 32605253 Free PMC article. Review.
Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells.
Sagnella SM, Yang L, Stubbs GE, Boslem E, Martino-Echarri E, Smolarczyk K, Pattison SL, Vanegas N, St Clair E, Clarke S, Boockvar J, MacDiarmid JA, Brahmbhatt H. Sagnella SM, et al. Among authors: boslem e. Cancer Cell. 2020 Mar 16;37(3):354-370.e7. doi: 10.1016/j.ccell.2020.02.001. Cancer Cell. 2020. PMID: 32183951 Clinical Trial.