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Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF. Pindel EV, et al. J Biol Chem. 1997 Jun 6;272(23):14769-75. doi: 10.1074/jbc.272.23.14769. J Biol Chem. 1997. PMID: 9169443
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF. Sanghani SP, et al. Among authors: bosron wf. Drug Metab Dispos. 2004 May;32(5):505-11. doi: 10.1124/dmd.32.5.505. Drug Metab Dispos. 2004. PMID: 15100172
Alcohol and aldehyde dehydrogenase.
Ehrig T, Bosron WF, Li TK. Ehrig T, et al. Alcohol Alcohol. 1990;25(2-3):105-16. doi: 10.1093/oxfordjournals.alcalc.a044985. Alcohol Alcohol. 1990. PMID: 2198030 Review.
Genetic variability of enzymes of alcohol metabolism in human beings.
Li TK, Bosron WF. Li TK, et al. Ann Emerg Med. 1986 Sep;15(9):997-1004. doi: 10.1016/s0196-0644(86)80118-4. Ann Emerg Med. 1986. PMID: 3526998 Review.
Catalytic properties of human liver alcohol dehydrogenase isoenzymes.
Bosron WF, Li TK. Bosron WF, et al. Enzyme. 1987;37(1-2):19-28. doi: 10.1159/000469238. Enzyme. 1987. PMID: 3569190
Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.
Jörnvall H, Hempel J, Vallee BL, Bosron WF, Li TK. Jörnvall H, et al. Proc Natl Acad Sci U S A. 1984 May;81(10):3024-8. doi: 10.1073/pnas.81.10.3024. Proc Natl Acad Sci U S A. 1984. PMID: 6374651 Free PMC article.
Effect of fasting on the activity and turnover of rat liver alcohol dehydrogenase.
Bosron WF, Crabb DW, Housinger TA, Li TK. Bosron WF, et al. Alcohol Clin Exp Res. 1984 Mar-Apr;8(2):196-200. doi: 10.1111/j.1530-0277.1984.tb05837.x. Alcohol Clin Exp Res. 1984. PMID: 6375431
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