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Proliferation of human malignant astrocytomas is dependent on Ras activation.
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Guha A, et al. Among authors: boss g. Oncogene. 1997 Dec 4;15(23):2755-65. doi: 10.1038/sj.onc.1201455. Oncogene. 1997. PMID: 9419966
Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity.
Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB. Chen JC, et al. Among authors: boss gr. J Biol Chem. 2003 Jan 31;278(5):2807-18. doi: 10.1074/jbc.M207943200. Epub 2002 Nov 11. J Biol Chem. 2003. PMID: 12429740
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells.
Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S, Worley PF, Boss GR, Pilz RB. Im E, et al. Among authors: boss gr. Oncogene. 2002 Sep 12;21(41):6356-65. doi: 10.1038/sj.onc.1205792. Oncogene. 2002. PMID: 12214276
Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation.
Raepple D, von Lintig F, Zemojtel T, Duchniewicz M, Jung A, Lübbert M, Boss GR, Scheele JS. Raepple D, et al. Among authors: boss gr. Ann Hematol. 2009 Apr;88(4):319-24. doi: 10.1007/s00277-008-0593-6. Epub 2008 Sep 11. Ann Hematol. 2009. PMID: 18784923 Free PMC article.
Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.
Guha A, Lau N, Huvar I, Gutmann D, Provias J, Pawson T, Boss G. Guha A, et al. Among authors: boss g. Oncogene. 1996 Feb 1;12(3):507-13. Oncogene. 1996. PMID: 8637706
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, Guha A. Lau N, et al. Among authors: boss gr. Int J Oncol. 2003 Jan;22(1):195-200. Int J Oncol. 2003. PMID: 12469204
Aberrant G protein signaling in nervous system tumors.
Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. Woods SA, et al. Among authors: boss g. J Neurosurg. 2002 Sep;97(3):627-42. doi: 10.3171/jns.2002.97.3.0627. J Neurosurg. 2002. PMID: 12296648 Review.
In this paper, the authors review G protein signaling in general and its aberrations in four human nervous system tumors. METHODS: In the nervous system, four tumor types have been associated with aberrant G protein signaling. ...The fourth tumor type includes a sig …
In this paper, the authors review G protein signaling in general and its aberrations in four human nervous system tumors. METHODS: In …
Ras activation in human breast cancer.
von Lintig FC, Dreilinger AD, Varki NM, Wallace AM, Casteel DE, Boss GR. von Lintig FC, et al. Among authors: boss gr. Breast Cancer Res Treat. 2000 Jul;62(1):51-62. doi: 10.1023/a:1006491619920. Breast Cancer Res Treat. 2000. PMID: 10989985
Haploid loss of Ki-ras delays mammary tumor progression in C3 (1)/SV40 Tag transgenic mice.
Liu ML, Shibata MA, Von Lintig FC, Wang W, Cassenaer S, Boss GR, Green JE. Liu ML, et al. Among authors: boss gr. Oncogene. 2001 Apr 12;20(16):2044-9. doi: 10.1038/sj.onc.1204280. Oncogene. 2001. PMID: 11360188
Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells.
Gudi S, Huvar I, White CR, McKnight NL, Dusserre N, Boss GR, Frangos JA. Gudi S, et al. Among authors: boss gr. Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):994-1000. doi: 10.1161/01.ATV.0000073314.51987.84. Epub 2003 Apr 24. Arterioscler Thromb Vasc Biol. 2003. PMID: 12714438
The small G protein Ras has been identified as an early link between rapid mechanotransduction events and the effects of shear stress on downstream signal-transduction cascades. ...
The small G protein Ras has been identified as an early link between rapid mechanotransduction events and the effects of shear stress …
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