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The immunological synapse of CTL contains a secretory domain and membrane bridges.
Stinchcombe JC, Bossi G, Booth S, Griffiths GM. Stinchcombe JC, et al. Among authors: bossi g. Immunity. 2001 Nov;15(5):751-61. doi: 10.1016/s1074-7613(01)00234-5. Immunity. 2001. PMID: 11728337
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
Holt O, Kanno E, Bossi G, Booth S, Daniele T, Santoro A, Arico M, Saegusa C, Fukuda M, Griffiths GM. Holt O, et al. Among authors: bossi g. Traffic. 2008 Apr;9(4):446-57. doi: 10.1111/j.1600-0854.2008.00714.x. Epub 2008 Feb 11. Traffic. 2008. PMID: 18266782 Free PMC article.
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.
Zuccato E, Blott EJ, Holt O, Sigismund S, Shaw M, Bossi G, Griffiths GM. Zuccato E, et al. Among authors: bossi g. J Cell Sci. 2007 Jan 1;120(Pt 1):191-9. doi: 10.1242/jcs.03315. Epub 2006 Dec 12. J Cell Sci. 2007. PMID: 17164290
Centrosome polarization delivers secretory granules to the immunological synapse.
Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM. Stinchcombe JC, et al. Among authors: bossi g. Nature. 2006 Sep 28;443(7110):462-5. doi: 10.1038/nature05071. Nature. 2006. PMID: 17006514
Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.
Bossi G, Booth S, Clark R, Davis EG, Liesner R, Richards K, Starcevic M, Stinchcombe J, Trambas C, Dell'Angelica EC, Griffiths GM. Bossi G, et al. Traffic. 2005 Mar;6(3):243-51. doi: 10.1111/j.1600-0854.2005.00264.x. Traffic. 2005. PMID: 15702992
CTL secretory lysosomes: biogenesis and secretion of a harmful organelle.
Bossi G, Griffiths GM. Bossi G, et al. Semin Immunol. 2005 Feb;17(1):87-94. doi: 10.1016/j.smim.2004.09.007. Semin Immunol. 2005. PMID: 15582491 Review.
Linking albinism and immunity: the secrets of secretory lysosomes.
Stinchcombe J, Bossi G, Griffiths GM. Stinchcombe J, et al. Among authors: bossi g. Science. 2004 Jul 2;305(5680):55-9. doi: 10.1126/science.1095291. Science. 2004. PMID: 15232098 Review.
The secretory synapse: the secrets of a serial killer.
Bossi G, Trambas C, Booth S, Clark R, Stinchcombe J, Griffiths GM. Bossi G, et al. Immunol Rev. 2002 Nov;189:152-60. doi: 10.1034/j.1600-065x.2002.18913.x. Immunol Rev. 2002. PMID: 12445272 Review.
Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.
Clark RH, Stinchcombe JC, Day A, Blott E, Booth S, Bossi G, Hamblin T, Davies EG, Griffiths GM. Clark RH, et al. Among authors: bossi g. Nat Immunol. 2003 Nov;4(11):1111-20. doi: 10.1038/ni1000. Epub 2003 Oct 19. Nat Immunol. 2003. PMID: 14566336
Sorting out the multiple roles of Fas ligand.
Bossi G, Stinchcombe JC, Page LJ, Griffiths GM. Bossi G, et al. Eur J Cell Biol. 2000 Aug;79(8):539-43. doi: 10.1078/0171-9335-00077. Eur J Cell Biol. 2000. PMID: 11001490 Review.
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