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Cooling and hemodynamic management in heatstroke: practical recommendations.
Bouchama A, Dehbi M, Chaves-Carballo E. Bouchama A, et al. Crit Care. 2007;11(3):R54. doi: 10.1186/cc5910. Crit Care. 2007. PMID: 17498312 Free PMC article. Review.
No evidence of a specific endpoint temperature for safe cessation of cooling was found. The circulatory alterations in heatstroke were due mostly to a form of distributive shock associated with relative or absolute hypovolemia. ...CONCLUSION: A systematic rev …
No evidence of a specific endpoint temperature for safe cessation of cooling was found. The circulatory alterations in heatstroke wer …
Elevated pyrogenic cytokines in heatstroke.
Bouchama A, al-Sedairy S, Siddiqui S, Shail E, Rezeig M. Bouchama A, et al. Chest. 1993 Nov;104(5):1498-502. doi: 10.1378/chest.104.5.1498. Chest. 1993. PMID: 8222814
We measured C-reactive protein (CRP) as a marker of acute phase response and calculated severity of illness using the simplified acute physiology score. ...CONCLUSION: Our findings of elevated circulating IL-6, IL-1 beta, and INF-gamma in the presence of acute phase respon …
We measured C-reactive protein (CRP) as a marker of acute phase response and calculated severity of illness using the simplified acut …
sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy.
Arabi YM, Dehbi M, Rishu AH, Baturcam E, Kahoul SH, Brits RJ, Naidu B, Bouchama A. Arabi YM, et al. Among authors: bouchama a. Crit Care. 2011 Aug 26;15(4):R203. doi: 10.1186/cc10420. Crit Care. 2011. PMID: 21871056 Free PMC article. Clinical Trial.
METHODS: A predesigned analysis was conducted of prospectively collected samples from 76 hyperglycemic critically ill patients (33 type-2 diabetes, 43 non-diabetes) aged ≥ 18 years with blood glucose of > 6.1 mmol/L enrolled in a randomized controlled trial compa …
METHODS: A predesigned analysis was conducted of prospectively collected samples from 76 hyperglycemic critically ill patients (33 ty …
Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon.
Bouchama A, Al-Mohanna F, Assad L, Baturcam E, Eldali A, Owaidah T, Dehbi M. Bouchama A, et al. Crit Care Med. 2012 Apr;40(4):1229-36. doi: 10.1097/CCM.0b013e3182387bef. Crit Care Med. 2012. PMID: 22080642
INTERVENTIONS: Twelve anesthetized baboons assigned randomly to recombinant nematode anticoagulant protein c2, a powerful inhibitor of tissue factor/factor VIIa-dependent coagulation (n = 6), or a control group (n = 6) were heat-stressed in a prewarmed neonat …
INTERVENTIONS: Twelve anesthetized baboons assigned randomly to recombinant nematode anticoagulant protein c2, a powerful inhibitor o …
Heatstroke: facing the threat.
Bouchama A. Bouchama A. Crit Care Med. 2006 Apr;34(4):1272-3. doi: 10.1097/01.CCM.0000208354.85490.45. Crit Care Med. 2006. PMID: 16550089 No abstract available.
Heatstroke.
Al Mahri S, Bouchama A. Al Mahri S, et al. Among authors: bouchama a. Handb Clin Neurol. 2018;157:531-545. doi: 10.1016/B978-0-444-64074-1.00032-X. Handb Clin Neurol. 2018. PMID: 30459024 Review.
Heat stroke.
Leon LR, Bouchama A. Leon LR, et al. Among authors: bouchama a. Compr Physiol. 2015 Apr;5(2):611-47. doi: 10.1002/cphy.c140017. Compr Physiol. 2015. PMID: 25880507 Review.
Toll-like receptor 4 and high-mobility group box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke.
Dehbi M, Uzzaman T, Baturcam E, Eldali A, Ventura W, Bouchama A. Dehbi M, et al. Among authors: bouchama a. PLoS One. 2012;7(9):e44100. doi: 10.1371/journal.pone.0044100. Epub 2012 Sep 4. PLoS One. 2012. PMID: 22962600 Free PMC article.
A sham-heated group served as a control. Mutant mice displayed more histological liver damage and higher mortality compared with wild type mice (73% vs. 27%, respectively, P<0.001). ...Specific inhibition of HMGB1 activity with DNA-binding A Box (600 µg/mo
A sham-heated group served as a control. Mutant mice displayed more histological liver damage and higher mortality compared wi
Hsp-72, a candidate prognostic indicator of heatstroke.
Dehbi M, Baturcam E, Eldali A, Ahmed M, Kwaasi A, Chishti MA, Bouchama A. Dehbi M, et al. Among authors: bouchama a. Cell Stress Chaperones. 2010 Sep;15(5):593-603. doi: 10.1007/s12192-010-0172-3. Epub 2010 Feb 23. Cell Stress Chaperones. 2010. PMID: 20174993 Free PMC article.
ELISA studies indicated a marked release of Hsp-72 into the circulation of baboons with severe heatstroke with a peak at 24 h post-heatstroke onset and remained sustained up to 72 h. ...They also suggest that extracellular Hsp-72 is a marker of multiple organ …
ELISA studies indicated a marked release of Hsp-72 into the circulation of baboons with severe heatstroke with a peak at 24 h …
Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke.
Bouchama A, Kunzelmann C, Dehbi M, Kwaasi A, Eldali A, Zobairi F, Freyssinet JM, de Prost D. Bouchama A, et al. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1318-25. doi: 10.1161/ATVBAHA.107.161737. Epub 2008 May 1. Arterioscler Thromb Vasc Biol. 2008. PMID: 18451327
Heat stress induced coagulation and fibrinolysis activation as evidenced by a significant increase from baseline levels in plasma levels of thrombin-antithrombin (TAT) complexes, tissue plasminogen activator, and D-dimer. ...Inhibition of MPs by rhAPC suggested a no …
Heat stress induced coagulation and fibrinolysis activation as evidenced by a significant increase from baseline levels in plasma lev …
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