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Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy.
Coffey JC, Wang JH, Smith MJ, Laing A, Bouchier-Hayes D, Cotter TG, Redmond HP. Coffey JC, et al. J Biol Chem. 2005 Jun 3;280(22):20968-77. doi: 10.1074/jbc.M414696200. Epub 2005 Mar 1. J Biol Chem. 2005. PMID: 15741161
Oncological implications of hypoxia inducible factor-1alpha (HIF-1alpha) expression.
O'Donnell JL, Joyce MR, Shannon AM, Harmey J, Geraghty J, Bouchier-Hayes D. O'Donnell JL, et al. Cancer Treat Rev. 2006 Oct;32(6):407-16. doi: 10.1016/j.ctrv.2006.05.003. Epub 2006 Aug 4. Cancer Treat Rev. 2006. PMID: 16889900 Review.
Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion.
Harmey JH, Bucana CD, Lu W, Byrne AM, McDonnell S, Lynch C, Bouchier-Hayes D, Dong Z. Harmey JH, et al. Int J Cancer. 2002 Oct 10;101(5):415-22. doi: 10.1002/ijc.10632. Int J Cancer. 2002. PMID: 12216068
Infiltrating immune cells, but not tumour cells, express FasL in non-small cell lung cancer: No association with prognosis identified in 3-year follow-up.
Toomey D, Smyth G, Condron C, Kelly J, Byrne AM, Kay E, Conroy RM, Broe P, Bouchier-Hayes D. Toomey D, et al. Int J Cancer. 2003 Jan 20;103(3):408-12. doi: 10.1002/ijc.10836. Int J Cancer. 2003. PMID: 12471625
Pretreatment with omega-3 fatty acid infusion to prevent leukocyte-endothelial injury responses seen in cardiac surgery.
McGuinness J, Byrne J, Condron C, McCarthy J, Bouchier-Hayes D, Redmond JM. McGuinness J, et al. J Thorac Cardiovasc Surg. 2008 Jul;136(1):135-41. doi: 10.1016/j.jtcvs.2007.11.010. Epub 2008 May 22. J Thorac Cardiovasc Surg. 2008. PMID: 18603066
Fracture hematoma is a potent proinflammatory mediator of neutrophil function.
Timlin M, Toomey D, Condron C, Power C, Street J, Murray P, Bouchier-Hayes D. Timlin M, et al. J Trauma. 2005 Jun;58(6):1223-9. doi: 10.1097/01.ta.0000169866.88781.f1. J Trauma. 2005. PMID: 15995474
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