Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

29 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression.
Bougdour A, Tardieux I, Hakimi MA. Bougdour A, et al. Cell Microbiol. 2014 Mar;16(3):334-43. doi: 10.1111/cmi.12255. Epub 2014 Jan 20. Cell Microbiol. 2014. PMID: 24373221 Review.
Toxoplasma gondii is the most widespread apicomplexan parasite and occupies a large spectrum of niches by infecting virtually any warm-blooded animals. ...Short and long-term intracellular survival is associated with Toxoplasma ability to both evade the host deleterious im …
Toxoplasma gondii is the most widespread apicomplexan parasite and occupies a large spectrum of niches by infecting virtually any war …
Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure.
Bougdour A, Sautel CF, Cannella D, Braun L, Hakimi MA. Bougdour A, et al. Parasite. 2008 Sep;15(3):206-10. doi: 10.1051/parasite/2008153206. Parasite. 2008. PMID: 18814682 Review.
The activity state of a gene is determined by a complex regulatory network of co-acting factors affecting the structure of the chromatin into which the gene is embedded. ...
The activity state of a gene is determined by a complex regulatory network of co-acting factors affecting the structure of the …
Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites.
Bougdour A, Maubon D, Baldacci P, Ortet P, Bastien O, Bouillon A, Barale JC, Pelloux H, Ménard R, Hakimi MA. Bougdour A, et al. J Exp Med. 2009 Apr 13;206(4):953-66. doi: 10.1084/jem.20082826. Epub 2009 Apr 6. J Exp Med. 2009. PMID: 19349466 Free PMC article.
We investigated the anti-Apicomplexa effect of FR235222, a histone deacetylase inhibitor (HDACi). We show that FR235222 is active against a variety of Apicomplexa genera, including Plasmodium and Toxoplasma, and is more potent than other HDACi's such as trichostatin …
We investigated the anti-Apicomplexa effect of FR235222, a histone deacetylase inhibitor (HDACi). We show that FR235222 is active aga …
Chromatin modifications: implications in the regulation of gene expression in Toxoplasma gondii.
Bougdour A, Braun L, Cannella D, Hakimi MA. Bougdour A, et al. Cell Microbiol. 2010 Apr 1;12(4):413-23. doi: 10.1111/j.1462-5822.2010.01446.x. Epub 2010 Jan 26. Cell Microbiol. 2010. PMID: 20109158 Review.
The apicomplexan Toxoplasma gondii completes its life cycle by successive processes of parasite differentiation that rely on a tight control of gene expression to ensure appropriate protein profiles on time. ...This review is a synthesis of the current knowledge of …
The apicomplexan Toxoplasma gondii completes its life cycle by successive processes of parasite differentiation that rely on a tight …
Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.
Bougdour A, Durandau E, Brenier-Pinchart MP, Ortet P, Barakat M, Kieffer S, Curt-Varesano A, Curt-Bertini RL, Bastien O, Coute Y, Pelloux H, Hakimi MA. Bougdour A, et al. Cell Host Microbe. 2013 Apr 17;13(4):489-500. doi: 10.1016/j.chom.2013.03.002. Cell Host Microbe. 2013. PMID: 23601110
After invading host cells, Toxoplasma gondii multiplies within a parasitophorous vacuole (PV) that is maintained by parasite proteins secreted from organelles called dense granules. ...Therefore, GRA16 represents a potentially emerging subfamily of exported dense gr …
After invading host cells, Toxoplasma gondii multiplies within a parasitophorous vacuole (PV) that is maintained by parasite proteins …
A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation.
Braun L, Brenier-Pinchart MP, Yogavel M, Curt-Varesano A, Curt-Bertini RL, Hussain T, Kieffer-Jaquinod S, Coute Y, Pelloux H, Tardieux I, Sharma A, Belrhali H, Bougdour A, Hakimi MA. Braun L, et al. Among authors: bougdour a. J Exp Med. 2013 Sep 23;210(10):2071-86. doi: 10.1084/jem.20130103. Epub 2013 Sep 16. J Exp Med. 2013. PMID: 24043761 Free PMC article.
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. ...We report that Toxoplasma secretes GRA24, a novel dense granule protein which traffics from the vacuole to the …
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasi …
miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.
Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA. Cannella D, et al. Among authors: bougdour a. Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27. Cell Rep. 2014. PMID: 24582962 Free PMC article.
In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, …
In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with …
Toxoplasma's ways of manipulating the host transcriptome via secreted effectors.
Hakimi MA, Bougdour A. Hakimi MA, et al. Among authors: bougdour a. Curr Opin Microbiol. 2015 Aug;26:24-31. doi: 10.1016/j.mib.2015.04.003. Epub 2015 Apr 24. Curr Opin Microbiol. 2015. PMID: 25912924 Review.
The obligate intracellular parasite Toxoplasma gondii strikes a subtle balance with the host immune system that not only prevents host death but also promotes parasite persistence. Although being enclosed within a parasitophorous vacuole, the parasite actively inter …
The obligate intracellular parasite Toxoplasma gondii strikes a subtle balance with the host immune system that not only prevents hos …
The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.
Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. Gold DA, et al. Among authors: bougdour a. Cell Host Microbe. 2015 May 13;17(5):642-52. doi: 10.1016/j.chom.2015.04.003. Cell Host Microbe. 2015. PMID: 25974303 Free PMC article.
GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a
GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance …
The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cells.
Curt-Varesano A, Braun L, Ranquet C, Hakimi MA, Bougdour A. Curt-Varesano A, et al. Among authors: bougdour a. Cell Microbiol. 2016 Feb;18(2):151-67. doi: 10.1111/cmi.12498. Epub 2015 Sep 6. Cell Microbiol. 2016. PMID: 26270241
With regard to export mechanism, a wealth of information in Plasmodium spp. is available, while the mechanisms operating in T. gondii remain uncertain. ...Because the first element contains a putative Plasmodium export element linear motif (RRLAE), we hypothesized t …
With regard to export mechanism, a wealth of information in Plasmodium spp. is available, while the mechanisms operating in T. gondii …
29 results
Jump to page
Feedback