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Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).
van Halteren AG, van Etten E, de Jong EC, Bouillon R, Roep BO, Mathieu C. van Halteren AG, et al. Diabetes. 2002 Jul;51(7):2119-25. doi: 10.2337/diabetes.51.7.2119. Diabetes. 2002. PMID: 12086941
1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543).
Overbergh L, Decallonne B, Waer M, Rutgeerts O, Valckx D, Casteels KM, Laureys J, Bouillon R, Mathieu C. Overbergh L, et al. Diabetes. 2000 Aug;49(8):1301-7. doi: 10.2337/diabetes.49.8.1301. Diabetes. 2000. PMID: 10923629
1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice.
Mathieu C, Laureys J, Sobis H, Vandeputte M, Waer M, Bouillon R. Mathieu C, et al. Diabetes. 1992 Nov;41(11):1491-5. doi: 10.2337/diab.41.11.1491. Diabetes. 1992. PMID: 1397723
Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory.
Giulietti A, van Etten E, Overbergh L, Stoffels K, Bouillon R, Mathieu C. Giulietti A, et al. Diabetes Res Clin Pract. 2007 Jul;77(1):47-57. doi: 10.1016/j.diabres.2006.10.007. Epub 2006 Nov 16. Diabetes Res Clin Pract. 2007. PMID: 17112620
Acute shock induced by antigen vaccination in NOD mice.
Overbergh L, Decallonne B, Branisteanu DD, Valckx D, Kasran A, Bouillon R, Mathieu C. Overbergh L, et al. Diabetes. 2003 Feb;52(2):335-41. doi: 10.2337/diabetes.52.2.335. Diabetes. 2003. PMID: 12540605

Serum IgE levels and Th(1)/Th(2) cytokine profile analysis showed that the shock phenomenon was paralleled by a Th(2) response. mRNA expression of platelet-activating factor receptor (PAF-R) was significantly higher in NOD mice (P < 0.01) and was further increased by 1a

Serum IgE levels and Th(1)/Th(2) cytokine profile analysis showed that the shock phenomenon was paralleled by a Th(2) response. mRNA express …
Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor.
Gysemans C, van Etten E, Overbergh L, Giulietti A, Eelen G, Waer M, Verstuyf A, Bouillon R, Mathieu C. Gysemans C, et al. Diabetes. 2008 Jan;57(1):269-75. doi: 10.2337/db07-1095. Epub 2007 Oct 24. Diabetes. 2008. PMID: 17959935
NOD bone marrow-derived dendritic cells are modulated by analogs of 1,25-dihydroxyvitamin D3.
van Etten E, Decallonne B, Bouillon R, Mathieu C. van Etten E, et al. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):457-9. doi: 10.1016/j.jsbmb.2004.03.017. J Steroid Biochem Mol Biol. 2004. PMID: 15225820
Analogs of 1alpha,25-dihydroxyvitamin D3 as pluripotent immunomodulators.
Van Etten E, Decallonne B, Verlinden L, Verstuyf A, Bouillon R, Mathieu C. Van Etten E, et al. J Cell Biochem. 2003 Feb 1;88(2):223-6. doi: 10.1002/jcb.10329. J Cell Biochem. 2003. PMID: 12520518 Review.
Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog.
Vanoirbeek E, Eelen G, Verlinden L, Marchal K, Engelen K, De Moor B, Beullens I, Marcelis S, De Clercq P, Bouillon R, Verstuyf A. Vanoirbeek E, et al. Anticancer Res. 2009 Sep;29(9):3585-90. Anticancer Res. 2009. PMID: 19667152
1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.
Gonzalez-Pardo V, Martin D, Gutkind JS, Verstuyf A, Bouillon R, de Boland AR, Boland RL. Gonzalez-Pardo V, et al. Endocrinology. 2010 Jan;151(1):23-31. doi: 10.1210/en.2009-0650. Epub 2009 Nov 13. Endocrinology. 2010. PMID: 19915163
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