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Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis
Boulanger C, et al. Int J Antimicrob Agents 2020. PMID 31704214
Primary endpoints were a lopinavir trough concentration (C(min)) >1.0 µg/mL and a rifampicin maximum concentration (C(max)) of 8-24 µg/mL. ...All patients met lopinavir C(max) and AUC(0-12) targets. Five patients achieved the primary endpoint of rifampicin C(max) (≥8 µg/mL) in at least one of the PK samplings, and five achieved the minimum rifampicin AUC(0-24) (≥44 µg·h/mL). ...
Primary endpoints were a lopinavir trough concentration (C(min)) >1.0 µg/mL and a rifampicin maximum concentration (C(max)) …
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