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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.
Belan O, Sebald M, Adamowicz M, Anand R, Vancevska A, Neves J, Grinkevich V, Hewitt G, Segura-Bayona S, Bellelli R, Robinson HMR, Higgins GS, Smith GCM, West SC, Rueda DS, Boulton SJ. Belan O, et al. Among authors: boulton sj. Mol Cell. 2022 Dec 15;82(24):4664-4680.e9. doi: 10.1016/j.molcel.2022.11.008. Epub 2022 Nov 30. Mol Cell. 2022. PMID: 36455556 Free article.
RTEL1 maintains genomic stability by suppressing homologous recombination.
Barber LJ, Youds JL, Ward JD, McIlwraith MJ, O'Neil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB, Auclair M, Tissenbaum H, West SC, Rose AM, Boulton SJ. Barber LJ, et al. Among authors: boulton sj. Cell. 2008 Oct 17;135(2):261-71. doi: 10.1016/j.cell.2008.08.016. Cell. 2008. PMID: 18957201 Free PMC article.
Mechanisms of DNA-protein crosslink repair.
Stingele J, Bellelli R, Boulton SJ. Stingele J, et al. Among authors: boulton sj. Nat Rev Mol Cell Biol. 2017 Sep;18(9):563-573. doi: 10.1038/nrm.2017.56. Epub 2017 Jun 28. Nat Rev Mol Cell Biol. 2017. PMID: 28655905 Review.
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S. Lehmann LC, et al. Among authors: boulton sj. Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017. Mol Cell. 2017. PMID: 29220652 Free PMC article.
Beyond PARP-POLθ as an anticancer target.
Higgins GS, Boulton SJ. Higgins GS, et al. Among authors: boulton sj. Science. 2018 Mar 16;359(6381):1217-1218. doi: 10.1126/science.aar5149. Science. 2018. PMID: 29590065 No abstract available.
159 results