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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. Sachs N, et al. Among authors: Bounova G. Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7. Cell. 2018. PMID: 29224780 Free article.
Prospective derivation of a living organoid biobank of colorectal cancer patients.
van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, van Houdt W, van Gorp J, Taylor-Weiner A, Kester L, McLaren-Douglas A, Blokker J, Jaksani S, Bartfeld S, Volckman R, van Sluis P, Li VS, Seepo S, Sekhar Pedamallu C, Cibulskis K, Carter SL, McKenna A, Lawrence MS, Lichtenstein L, Stewart C, Koster J, Versteeg R, van Oudenaarden A, Saez-Rodriguez J, Vries RG, Getz G, Wessels L, Stratton MR, McDermott U, Meyerson M, Garnett MJ, Clevers H. van de Wetering M, et al. Among authors: Bounova G. Cell. 2015 May 7;161(4):933-45. doi: 10.1016/j.cell.2015.03.053. Cell. 2015. PMID: 25957691 Free PMC article.
Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition.
Koppens MA, Bounova G, Cornelissen-Steijger P, de Vries N, Sansom OJ, Wessels LF, van Lohuizen M. Koppens MA, et al. Among authors: Bounova G. Oncotarget. 2016 Oct 25;7(43):69816-69828. doi: 10.18632/oncotarget.12002. Oncotarget. 2016. PMID: 27634879 Free PMC article.
Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.
Koppens MA, Bounova G, Gargiulo G, Tanger E, Janssen H, Cornelissen-Steijger P, Blom M, Song JY, Wessels LF, van Lohuizen M. Koppens MA, et al. Among authors: Bounova G. Gastroenterology. 2016 Oct;151(4):684-697.e12. doi: 10.1053/j.gastro.2016.06.020. Epub 2016 Jun 21. Gastroenterology. 2016. PMID: 27342214
Quantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization.
Bonhoure N, Bounova G, Bernasconi D, Praz V, Lammers F, Canella D, Willis IM, Herr W, Hernandez N, Delorenzi M; CycliX Consortium. Bonhoure N, et al. Among authors: Bounova G. Genome Res. 2014 Jul;24(7):1157-68. doi: 10.1101/gr.168260.113. Epub 2014 Apr 7. Genome Res. 2014. PMID: 24709819 Free PMC article.
Consensus molecular subtype classification of colorectal adenomas.
Komor MA, Bosch LJ, Bounova G, Bolijn AS, Delis-van Diemen PM, Rausch C, Hoogstrate Y, Stubbs AP, de Jong M, Jenster G, van Grieken NC, Carvalho B, Wessels LF, Jimenez CR, Fijneman RJ, Meijer GA; NGS-ProToCol Consortium:. Komor MA, et al. Among authors: Bounova G. J Pathol. 2018 Nov;246(3):266-276. doi: 10.1002/path.5129. Epub 2018 Aug 31. J Pathol. 2018. PMID: 29968252 Free PMC article.
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.
Chalabi M, Fanchi LF, Dijkstra KK, Van den Berg JG, Aalbers AG, Sikorska K, Lopez-Yurda M, Grootscholten C, Beets GL, Snaebjornsson P, Maas M, Mertz M, Veninga V, Bounova G, Broeks A, Beets-Tan RG, de Wijkerslooth TR, van Lent AU, Marsman HA, Nuijten E, Kok NF, Kuiper M, Verbeek WH, Kok M, Van Leerdam ME, Schumacher TN, Voest EE, Haanen JB. Chalabi M, et al. Among authors: Bounova G. Nat Med. 2020 Apr 6. doi: 10.1038/s41591-020-0805-8. Online ahead of print. Nat Med. 2020. PMID: 32251400
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
Driehuis E, van Hoeck A, Moore K, Kolders S, Francies HE, Gulersonmez MC, Stigter ECA, Burgering B, Geurts V, Gracanin A, Bounova G, Morsink FH, Vries R, Boj S, van Es J, Offerhaus GJA, Kranenburg O, Garnett MJ, Wessels L, Cuppen E, Brosens LAA, Clevers H. Driehuis E, et al. Among authors: Bounova G. Proc Natl Acad Sci U S A. 2019 Dec 9;116(52):26580-90. doi: 10.1073/pnas.1911273116. Online ahead of print. Proc Natl Acad Sci U S A. 2019. PMID: 31818951
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