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The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity.
Zhang W, Teng H, Zhao T, Eglitis RI, Wang X, Yu Z, Qu S, Wang H, Zhao Y, Fan B, Liu S, Zhao Y. Zhang W, et al. Among authors: fan b. Front Pharmacol. 2025 Jan 15;15:1518810. doi: 10.3389/fphar.2024.1518810. eCollection 2024. Front Pharmacol. 2025. PMID: 39881873 Free PMC article.
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