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Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.
Johnson G, Drummond JT, Boxer PA, Bruns RF. Johnson G, et al. Among authors: boxer pa. J Med Chem. 1992 Jan 24;35(2):233-41. doi: 10.1021/jm00080a006. J Med Chem. 1992. PMID: 1310117
The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
Hu LY, Boxer PA, Kesten SR, Lei HJ, Wustrow DJ, Moreland DW, Zhang L, Ahn K, Ryder TR, Liu X, Rubin JR, Fahnoe K, Carroll RT, Dutta S, Fahnoe DC, Probert AW, Roof RL, Rafferty MF, Kostlan CR, Scholten JD, Hood M, Ren XD, Schielke GP, Su TZ, Taylor CP, Mistry A, McConnell P, Hasemann C, Ohren J. Hu LY, et al. Among authors: boxer pa. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. doi: 10.1016/j.bmcl.2005.07.058. Epub 2005 Sep 6. Bioorg Med Chem Lett. 2006. PMID: 16143519
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.
Wright JL, Gregory TF, Bigge CF, Boxer PA, Serpa K, Meltzer LT, Wise LD, Cai SX, Hawkinson JE, Konkoy CS, Whittemore ER, Woodward RM, Zhou ZL. Wright JL, et al. Among authors: boxer pa. J Med Chem. 1999 Jul 1;42(13):2469-77. doi: 10.1021/jm990148x. J Med Chem. 1999. PMID: 10395488
4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.
Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. Zhou ZL, et al. Among authors: boxer pa. J Med Chem. 1999 Jul 29;42(15):2993-3000. doi: 10.1021/jm990246i. J Med Chem. 1999. PMID: 10425109
Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives.
Nikam SS, Cordon JJ, Ortwine DF, Heimbach TH, Blackburn AC, Vartanian MG, Nelson CB, Schwarz RD, Boxer PA, Rafferty MF. Nikam SS, et al. Among authors: boxer pa. J Med Chem. 1999 Jun 17;42(12):2266-71. doi: 10.1021/jm980455n. J Med Chem. 1999. PMID: 10377233
The voltage-sensitive Ca2+ channel (VSCC) antagonists omega-Aga-IVA and omega-CTX-MVIIC inhibit spontaneous epileptiform discharges in the rat cortical wedge.
Robichaud LJ, Wurster S, Boxer PA. Robichaud LJ, et al. Among authors: boxer pa. Brain Res. 1994 Apr 18;643(1-2):352-6. doi: 10.1016/0006-8993(94)90047-7. Brain Res. 1994. PMID: 8032931
Substituted 2-benzothiazolamines as sodium flux inhibitors: quantitative structure-activity relationships and anticonvulsant activity.
Hays SJ, Rice MJ, Ortwine DF, Johnson G, Schwarz RD, Boyd DK, Copeland LF, Vartanian MG, Boxer PA. Hays SJ, et al. Among authors: boxer pa. J Pharm Sci. 1994 Oct;83(10):1425-32. doi: 10.1002/jps.2600831013. J Pharm Sci. 1994. PMID: 7884664
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. Among authors: boxer pa. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904
Polyamine modulation of excitatory amino acid responses in the rat cortical wedge.
Robichaud LJ, Boxer PA. Robichaud LJ, et al. Among authors: boxer pa. Neuropharmacology. 1993 Oct;32(10):1025-35. doi: 10.1016/0028-3908(93)90068-e. Neuropharmacology. 1993. PMID: 7507576
Identification and evaluation of O-alkyl substituted hydroxamic acids as potent in vitro inhibitors of the hepatic glycine cleavage system and investigation of their action on in vivo central nervous system glycine concentration.
Johnson G, Boxer PA, Drummond JT, Boyd DK, Anderson RJ. Johnson G, et al. Among authors: boxer pa. Arzneimittelforschung. 1989 Apr;39(4):432-7. Arzneimittelforschung. 1989. PMID: 2751729
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