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Alteration of the glycolipid binding specificity of the pig edema toxin from globotetraosyl to globotriaosyl ceramide alters in vivo tissue targetting and results in a verotoxin 1-like disease in pigs.
Boyd B, Tyrrell G, Maloney M, Gyles C, Brunton J, Lingwood C. Boyd B, et al. J Exp Med. 1993 Jun 1;177(6):1745-53. doi: 10.1084/jem.177.6.1745. J Exp Med. 1993. PMID: 8496689 Free PMC article.
We were recently able to identify, using site-directed mutagenesis, amino acids in the binding subunit of these toxins that are important in defining their glycosphingolipid (GSL) binding specificity (Tyrrell, G. J., K. Ramotar, B. Boyd, B. W. Toye, C. A. Lin …
We were recently able to identify, using site-directed mutagenesis, amino acids in the binding subunit of these toxins that are important in …
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