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Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.
Kostenuik PJ, Nguyen HQ, McCabe J, Warmington KS, Kurahara C, Sun N, Chen C, Li L, Cattley RC, Van G, Scully S, Elliott R, Grisanti M, Morony S, Tan HL, Asuncion F, Li X, Ominsky MS, Stolina M, Dwyer D, Dougall WC, Hawkins N, Boyle WJ, Simonet WS, Sullivan JK. Kostenuik PJ, et al. Among authors: boyle wj. J Bone Miner Res. 2009 Feb;24(2):182-95. doi: 10.1359/jbmr.081112. J Bone Miner Res. 2009. PMID: 19016581 Free article.
RANK-L and RANK: T cells, bone loss, and mammalian evolution.
Theill LE, Boyle WJ, Penninger JM. Theill LE, et al. Among authors: boyle wj. Annu Rev Immunol. 2002;20:795-823. doi: 10.1146/annurev.immunol.20.100301.064753. Epub 2001 Oct 4. Annu Rev Immunol. 2002. PMID: 11861618 Review.
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