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Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies.
Bowers PM, Horlick RA, Neben TY, Toobian RM, Tomlinson GL, Dalton JL, Jones HA, Chen A, Altobell L 3rd, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell A, Chau B, Holland T, Berkebile AD, Neben SS, Boyle WJ, King DJ. Bowers PM, et al. Among authors: boyle wj. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20455-60. doi: 10.1073/pnas.1114010108. Epub 2011 Dec 7. Proc Natl Acad Sci U S A. 2011. PMID: 22158898 Free PMC article.
Surrogate approaches in development of monoclonal antibodies.
Bornstein GG, Klakamp SL, Andrews L, Boyle WJ, Tabrizi M. Bornstein GG, et al. Among authors: boyle wj. Drug Discov Today. 2009 Dec;14(23-24):1159-65. doi: 10.1016/j.drudis.2009.09.014. Epub 2009 Oct 21. Drug Discov Today. 2009. PMID: 19853060 Review.
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.
Kostenuik PJ, Nguyen HQ, McCabe J, Warmington KS, Kurahara C, Sun N, Chen C, Li L, Cattley RC, Van G, Scully S, Elliott R, Grisanti M, Morony S, Tan HL, Asuncion F, Li X, Ominsky MS, Stolina M, Dwyer D, Dougall WC, Hawkins N, Boyle WJ, Simonet WS, Sullivan JK. Kostenuik PJ, et al. Among authors: boyle wj. J Bone Miner Res. 2009 Feb;24(2):182-95. doi: 10.1359/jbmr.081112. J Bone Miner Res. 2009. PMID: 19016581 Free article.
Osteoclast differentiation and activation.
Boyle WJ, Simonet WS, Lacey DL. Boyle WJ, et al. Nature. 2003 May 15;423(6937):337-42. doi: 10.1038/nature01658. Nature. 2003. PMID: 12748652 Review.
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