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Evaluating the real-world effectiveness of belimumab in patients with SLE using SLE-related laboratory values and rheumatoid arthritis-derived disease activity measures: RAPID3, swollen joint count and tender joint count.
Germain G, Worley K, MacKnight SD, Rubin B, Bell CF, Laliberté F, Urosevic A, Sheng Duh M, Concoff A. Germain G, et al. Lupus Sci Med. 2024 Apr 3;11(1):e001111. doi: 10.1136/lupus-2023-001111. Lupus Sci Med. 2024. PMID: 38575172 Free PMC article.
The primary outcome measure was time to first improvement of minimally important difference (MID) for Routine Assessment of Patient Index Data 3 (RAPID3), Patient Pain Index (PPI), swollen joint count, tender joint count (TJC), complement C3 and C4 and anti-double-stranded …
The primary outcome measure was time to first improvement of minimally important difference (MID) for Routine Assessment of Patient Index Da …
Novel Meta-Diamide Compounds Containing Sulfide Derivatives Were Designed and Synthesized as Potential Pesticides.
Wu J, Dang S, Zhang Y, Zhou S. Wu J, et al. Molecules. 2024 Mar 17;29(6):1337. doi: 10.3390/molecules29061337. Molecules. 2024. PMID: 38542973 Free PMC article.
Notably, for P. xylostella, compounds C-2, C-3, C-4 and D-2 demonstrated 60.00-100.00% insecticidal activity even at a concentration as low as 0.625 mg.L(-1). As determined by structure-activity relationship (SAR) analysis, compounds with R(1) = CH(3) and R(2) = Br …
Notably, for P. xylostella, compounds C-2, C-3, C-4 and D-2 demonstrated 60.00-100.00% insecticidal activity even at a concentration …
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis.
Olivero G, Taddeucci A, Vallarino G, Trebesova H, Roggeri A, Gagliani MC, Cortese K, Grilli M, Pittaluga A. Olivero G, et al. Br J Pharmacol. 2024 Feb 18. doi: 10.1111/bph.16328. Online ahead of print. Br J Pharmacol. 2024. PMID: 38369641
EXPERIMENTAL APPROACH: EAE cortical synaptosomes and gliosomes were analysed for glutamate release efficiency (measured as release of preloaded [(3) H]D-aspartate ([(3) H]D-ASP)), C1q and C3 protein density, and for viability and ongoing apoptosis. KEY RESULT …
EXPERIMENTAL APPROACH: EAE cortical synaptosomes and gliosomes were analysed for glutamate release efficiency (measured as release of preloa …
Testacosides A-D, glycoglycerolipids produced by Microbacterium testaceum isolated from Tedania brasiliensis.
Quintana-Bulla JI, Tonon LAC, Michaliski LF, Hajdu E, Ferreira AG, Berlinck RGS. Quintana-Bulla JI, et al. Appl Microbiol Biotechnol. 2024 Dec;108(1):112. doi: 10.1007/s00253-023-12870-0. Epub 2024 Jan 12. Appl Microbiol Biotechnol. 2024. PMID: 38217254 Free PMC article.
Molecular networking analysis of bioactive pre-fractionated extracts from culture media of M. testaceum enabled the discovery of testacosides A-D. Analysis of spectroscopic data and chemical derivatizations allowed the identification of testacosides A-D as glycoglyc …
Molecular networking analysis of bioactive pre-fractionated extracts from culture media of M. testaceum enabled the discovery of testacoside …
Reducing complement activation during sleep deprivation yields cognitive improvement by dexmedetomidine.
Zhai Q, Zhang Y, Ye M, Zhu S, Sun J, Wang Y, Deng B, Ma D, Wang Q. Zhai Q, et al. Br J Anaesth. 2023 Sep;131(3):542-555. doi: 10.1016/j.bja.2023.04.044. Epub 2023 Jul 29. Br J Anaesth. 2023. PMID: 37517957 Free article.
RESULTS: CSR mice displayed a decline in learning and memory by 12% (P<0.05) in the Y-maze and by 18% (P<0.01) in the novel object recognition test; these changes were associated with increases in microglial activation, CD68+ microglial phagosome counts, astrocyte-derived c …
RESULTS: CSR mice displayed a decline in learning and memory by 12% (P<0.05) in the Y-maze and by 18% (P<0.01) in the novel object rec …
Brominated [20]silafulleranes: pushing the limits of steric loading.
Bamberg M, Gasevic T, Bolte M, Virovets A, Lerner HW, Grimme S, Bursch M, Wagner M. Bamberg M, et al. Chem Commun (Camb). 2023 Jun 13;59(48):7459-7462. doi: 10.1039/d3cc02142d. Chem Commun (Camb). 2023. PMID: 37254708
Starting from the perhydrogenated silafullerane [nBu(4)N][Cl@Si(20)(SiH(3))(12)H(8)], treatment with BBr(3) leads to partially and exhaustively brominated clusters, [nBu(4)N][Cl@Si(20)(SiBr(2)H)(12)Br(8)] (120 eq. BBr(3), room temperature, 30 min) and [nBu(4)N][Cl@Si(20)(S …
Starting from the perhydrogenated silafullerane [nBu(4)N][Cl@Si(20)(SiH(3))(12)H(8)], treatment with BBr(3) leads to partially and exhaustiv …
Xylose isomerase from Piromyces sp. E2 is a promiscuous enzyme with epimerase activity.
Barreto MQ, Garbelotti CV, de Moura Soares J, Grandis A, Buckeridge MS, Leone FA, Ward RJ. Barreto MQ, et al. Enzyme Microb Technol. 2023 May;166:110230. doi: 10.1016/j.enzmictec.2023.110230. Epub 2023 Mar 21. Enzyme Microb Technol. 2023. PMID: 36966679
Xylose isomerase catalyzes the isomerization of D-xylose to D-xylulose with promiscuous activity for other saccharides including D-glucose, D-allose, and L-arabinose. ...We have measured the kinetic parameters of the PirE2_XI and analyzed its thermosta …
Xylose isomerase catalyzes the isomerization of D-xylose to D-xylulose with promiscuous activity for other saccharides includi …
173 results