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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Jensen AA, et al. J Med Chem. 2007 Aug 23;50(17):4177-85. doi: 10.1021/jm070532r. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672447
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.
Bräuner-Osborne H, Ebert B, Brann MR, Falch E, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. J Med Chem. 1995 Jun 9;38(12):2188-95. doi: 10.1021/jm00012a019. J Med Chem. 1995. PMID: 7783150
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
Bräuner-Osborne H, Sløk FA, Skjaerbaek N, Ebert B, Sekiyama N, Nakanishi S, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. J Med Chem. 1996 Aug 2;39(16):3188-94. doi: 10.1021/jm9602569. J Med Chem. 1996. PMID: 8759641
Functional partial agonism at cloned human muscarinic acetylcholine receptors.
Bräuner-Osborne H, Ebert B, Brann MR, Falch E, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. Eur J Pharmacol. 1996 Oct 10;313(1-2):145-50. doi: 10.1016/0014-2999(96)00501-8. Eur J Pharmacol. 1996. PMID: 8905341
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors.
Bräuner-Osborne H, Madsen U, Mikiciuk-Olasik E, Curry K. Bräuner-Osborne H, et al. Eur J Pharmacol. 1997 Aug 13;332(3):327-31. doi: 10.1016/s0014-2999(97)01098-4. Eur J Pharmacol. 1997. PMID: 9300268
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.
Ahmadian H, Nielsen B, Bräuner-Osborne H, Johansen TN, Stensbøl TB, Sløk FA, Sekiyama N, Nakanishi S, Krogsgaard-Larsen P, Madsen U. Ahmadian H, et al. J Med Chem. 1997 Oct 24;40(22):3700-5. doi: 10.1021/jm9703597. J Med Chem. 1997. PMID: 9357538
Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors.
Bráuner-Osborne H, Nielsen B, Stensbøl TB, Johansen TN, Skjaerbaek N, Krogsgaard-Larsen P. Bráuner-Osborne H, et al. Eur J Pharmacol. 1997 Sep 24;335(2-3):R1-3. doi: 10.1016/s0014-2999(97)01263-6. Eur J Pharmacol. 1997. PMID: 9369383
Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors.
Bräuner-Osborne H, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. Br J Pharmacol. 1998 Jan;123(2):269-74. doi: 10.1038/sj.bjp.0701616. Br J Pharmacol. 1998. PMID: 9489615 Free PMC article.
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Johansen TN, Ebert B, Bräuner-Osborne H, Didriksen M, Christensen IT, Søby KK, Madsen U, Krogsgaard-Larsen P, Brehm L. Johansen TN, et al. J Med Chem. 1998 Mar 12;41(6):930-9. doi: 10.1021/jm9706731. J Med Chem. 1998. PMID: 9526567
Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.
Bräuner-Osborne H, Nielsen B, Krogsgaard-Larsen P. Bräuner-Osborne H, et al. Eur J Pharmacol. 1998 Jun 5;350(2-3):311-6. doi: 10.1016/s0014-2999(98)00246-5. Eur J Pharmacol. 1998. PMID: 9696422
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