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Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics.
Mayer C, Sass P, Brötz-Oesterhelt H. Mayer C, et al. Among authors: brotz oesterhelt h. Int J Med Microbiol. 2019 Nov;309(7):151329. doi: 10.1016/j.ijmm.2019.151329. Epub 2019 Jul 14. Int J Med Microbiol. 2019. PMID: 31331697
Rhodomyrtone (Rom) is a membrane-active compound.
Saising J, Nguyen MT, Härtner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schäkermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F. Saising J, et al. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1114-1124. doi: 10.1016/j.bbamem.2018.01.011. Epub 2018 Jan 6. Biochim Biophys Acta Biomembr. 2018. PMID: 29317198
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability.
Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S. Schilling NA, et al. Among authors: brotz oesterhelt h. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. doi: 10.1002/anie.201901589. Epub 2019 May 27. Angew Chem Int Ed Engl. 2019. PMID: 31059155 Free PMC article.
Human commensals producing a novel antibiotic impair pathogen colonization.
Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B. Zipperer A, et al. Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634. Nature. 2016. PMID: 27466123
Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition.
Schüller A, Matzner D, Lünse CE, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G, Mayer G. Schüller A, et al. Chembiochem. 2017 Mar 2;18(5):435-440. doi: 10.1002/cbic.201600491. Epub 2017 Jan 30. Chembiochem. 2017. PMID: 28012261
Postgenomic strategies in antibacterial drug discovery.
Brötz-Oesterhelt H, Sass P. Brötz-Oesterhelt H, et al. Future Microbiol. 2010 Oct;5(10):1553-79. doi: 10.2217/fmb.10.119. Future Microbiol. 2010. PMID: 21073314 Review.
Bacterial cell division as a target for new antibiotics.
Sass P, Brötz-Oesterhelt H. Sass P, et al. Curr Opin Microbiol. 2013 Oct;16(5):522-30. doi: 10.1016/j.mib.2013.07.006. Epub 2013 Aug 8. Curr Opin Microbiol. 2013. PMID: 23932516 Review.
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, Hinzen B, Raddatz S, Paulsen H, Henninger K, Bandow JE, Sahl HG, Labischinski H. Brötz-Oesterhelt H, et al. Nat Med. 2005 Oct;11(10):1082-7. doi: 10.1038/nm1306. Epub 2005 Oct 2. Nat Med. 2005. PMID: 16200071
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H. Famulla K, et al. Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1. Mol Microbiol. 2016. PMID: 26919556 Free PMC article.
Bacterial caseinolytic proteases as novel targets for antibacterial treatment.
Brötz-Oesterhelt H, Sass P. Brötz-Oesterhelt H, et al. Int J Med Microbiol. 2014 Jan;304(1):23-30. doi: 10.1016/j.ijmm.2013.09.001. Epub 2013 Sep 4. Int J Med Microbiol. 2014. PMID: 24119566 Review.
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