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IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1α translation.
Dehne N, Tausendschön M, Essler S, Geis T, Schmid T, Brüne B. Dehne N, et al. Among authors: brune b. J Leukoc Biol. 2014 Jan;95(1):129-37. doi: 10.1189/jlb.0113045. Epub 2013 Sep 4. J Leukoc Biol. 2014. PMID: 24006507
Modulation of nitric oxide-evoked apoptosis by the p53-downstream target p21(WAF1/CIP1).
Yang F, von Knethen A, Brüne B. Yang F, et al. Among authors: brune b. J Leukoc Biol. 2000 Dec;68(6):916-22. J Leukoc Biol. 2000. PMID: 11129661
Accumulation of HIF-1alpha under the influence of nitric oxide.
Sandau KB, Fandrey J, Brüne B. Sandau KB, et al. Among authors: brune b. Blood. 2001 Feb 15;97(4):1009-15. doi: 10.1182/blood.v97.4.1009. Blood. 2001. PMID: 11159530
Transcription factors p53 and HIF-1alpha as targets of nitric oxide.
Brüne B, von Knethen A, Sandau KB. Brüne B, et al. Cell Signal. 2001 Aug;13(8):525-33. doi: 10.1016/s0898-6568(01)00175-9. Cell Signal. 2001. PMID: 11483405 Review.
NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells.
Zhou J, Fandrey J, Schümann J, Tiegs G, Brüne B. Zhou J, et al. Among authors: brune b. Am J Physiol Cell Physiol. 2003 Feb;284(2):C439-46. doi: 10.1152/ajpcell.00294.2002. Epub 2002 Sep 25. Am J Physiol Cell Physiol. 2003. PMID: 12388069
We show that signal transmission by NO with TNF-alpha in LLC-PK(1) cells is mediated via the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway, because it is blocked by wortmannin or dominant-negative forms of PI3-K as well as protein kinase B. ...
We show that signal transmission by NO with TNF-alpha in LLC-PK(1) cells is mediated via the phosphatidylinositol 3-kinase (PI3-K)/Akt pathw …
HIF-1 alpha protein as a target for S-nitrosation.
Sumbayev VV, Budde A, Zhou J, Brüne B. Sumbayev VV, et al. Among authors: brune b. FEBS Lett. 2003 Jan 30;535(1-3):106-12. doi: 10.1016/s0014-5793(02)03887-5. FEBS Lett. 2003. PMID: 12560087
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms.
Shatrov VA, Sumbayev VV, Zhou J, Brüne B. Shatrov VA, et al. Among authors: brune b. Blood. 2003 Jun 15;101(12):4847-9. doi: 10.1182/blood-2002-09-2711. Epub 2003 Feb 13. Blood. 2003. PMID: 12586627
The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha).
Brüne B, Zhou J. Brüne B, et al. Curr Med Chem. 2003 May;10(10):845-55. doi: 10.2174/0929867033457746. Curr Med Chem. 2003. PMID: 12678687 Review.
Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.
Tautenhahn A, Brüne B, von Knethen A. Tautenhahn A, et al. Among authors: brune b. J Leukoc Biol. 2003 May;73(5):665-72. doi: 10.1189/jlb.1002487. J Leukoc Biol. 2003. PMID: 12714582
Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway.
Zhou J, Schmid T, Brüne B. Zhou J, et al. Among authors: brune b. Mol Biol Cell. 2003 Jun;14(6):2216-25. doi: 10.1091/mbc.e02-09-0598. Epub 2003 Feb 6. Mol Biol Cell. 2003. PMID: 12808024 Free PMC article.
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