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Central insulin action in energy and glucose homeostasis.
Plum L, Belgardt BF, Brüning JC. Plum L, et al. Among authors: bruning jc. J Clin Invest. 2006 Jul;116(7):1761-6. doi: 10.1172/JCI29063. J Clin Invest. 2006. PMID: 16823473 Free PMC article. Review.
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Kulkarni RN, et al. Among authors: bruning jc. J Clin Invest. 1999 Dec;104(12):R69-75. doi: 10.1172/JCI8339. J Clin Invest. 1999. PMID: 10606633 Free PMC article.
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. Kido Y, et al. Among authors: bruning jc. J Clin Invest. 2000 Jan;105(2):199-205. doi: 10.1172/JCI7917. J Clin Invest. 2000. PMID: 10642598 Free PMC article.
Characterization of a postreceptor signaling defect that impairs cfos expression in cultured fibroblasts of a patient with insulin resistance.
Knebel B, Kotzka J, Avci H, Schiller M, Brüning JC, Hafner M, Krone W, Müller-Wieland D. Knebel B, et al. Among authors: bruning jc. Biochem Biophys Res Commun. 2000 Feb 16;268(2):577-82. doi: 10.1006/bbrc.2000.2185. Biochem Biophys Res Commun. 2000. PMID: 10679246
Role of brain insulin receptor in control of body weight and reproduction.
Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Müller-Wieland D, Kahn CR. Brüning JC, et al. Science. 2000 Sep 22;289(5487):2122-5. doi: 10.1126/science.289.5487.2122. Science. 2000. PMID: 11000114
Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.
Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Kahn CR, et al. Among authors: bruning jc. J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1377-84. doi: 10.1515/jpem-2000-s611. J Pediatr Endocrinol Metab. 2000. PMID: 11202213 Review.
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M. Guerra C, et al. J Clin Invest. 2001 Oct;108(8):1205-13. doi: 10.1172/JCI13103. J Clin Invest. 2001. PMID: 11602628 Free PMC article.
Genetic manipulation of the insulin signalling cascade in mice--potential insight into the pathomechanism of type 2 diabetes.
Baudler S, Krone W, Brüning JC. Baudler S, et al. Among authors: bruning jc. Best Pract Res Clin Endocrinol Metab. 2003 Sep;17(3):431-43. doi: 10.1016/s1521-690x(03)00039-3. Best Pract Res Clin Endocrinol Metab. 2003. PMID: 12962695 Review.
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance.
Röhl M, Pasparakis M, Baudler S, Baumgartl J, Gautam D, Huth M, De Lorenzi R, Krone W, Rajewsky K, Brüning JC. Röhl M, et al. Among authors: bruning jc. J Clin Invest. 2004 Feb;113(3):474-81. doi: 10.1172/JCI18712. J Clin Invest. 2004. PMID: 14755344 Free PMC article.
Role for neuronal insulin resistance in neurodegenerative diseases.
Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Küstermann E, Arndt S, Jacobs AH, Krone W, Kahn CR, Brüning JC. Schubert M, et al. Among authors: bruning jc. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3100-5. doi: 10.1073/pnas.0308724101. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981233 Free PMC article.
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