Brüning JC - Search Results

1

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.

Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Brüning JC, et al. Cell. 1997 Feb 21;88(4):561-72. doi: 10.1016/s0092-8674(00)81896-6. Cell. 1997. PMID: 9038347

2

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

Araki E, Lipes MA, Patti ME, Brüning JC, Haag B 3rd, Johnson RS, Kahn CR. Araki E, et al. Among authors: bruning jc. Nature. 1994 Nov 10;372(6502):186-90. doi: 10.1038/372186a0. Nature. 1994. PMID: 7526222

3

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.

Brüning JC, Winnay J, Cheatham B, Kahn CR. Brüning JC, et al. Mol Cell Biol. 1997 Mar;17(3):1513-21. doi: 10.1128/MCB.17.3.1513. Mol Cell Biol. 1997. PMID: 9032279 Free PMC article.

4

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.

Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR. Brüning JC, et al. Mol Cell. 1998 Nov;2(5):559-69. doi: 10.1016/s1097-2765(00)80155-0. Mol Cell. 1998. PMID: 9844629

5

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Kulkarni RN, et al. Among authors: bruning jc. Cell. 1999 Feb 5;96(3):329-39. doi: 10.1016/s0092-8674(00)80546-2. Cell. 1999. PMID: 10025399

6

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.

Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Kulkarni RN, et al. Among authors: bruning jc. J Clin Invest. 1999 Dec;104(12):R69-75. doi: 10.1172/JCI8339. J Clin Invest. 1999. PMID: 10606633 Free PMC article.

7

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. Kido Y, et al. Among authors: bruning jc. J Clin Invest. 2000 Jan;105(2):199-205. doi: 10.1172/JCI7917. J Clin Invest. 2000. PMID: 10642598 Free PMC article.

8

Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.

Winnay JN, Brüning JC, Burks DJ, Kahn CR. Winnay JN, et al. Among authors: bruning jc. J Biol Chem. 2000 Apr 7;275(14):10545-50. doi: 10.1074/jbc.275.14.10545. J Biol Chem. 2000. PMID: 10744748

9

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Kahn CR, et al. Among authors: bruning jc. J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1377-84. doi: 10.1515/jpem-2000-s611. J Pediatr Endocrinol Metab. 2000. PMID: 11202213 Review.

10

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M. Guerra C, et al. J Clin Invest. 2001 Oct;108(8):1205-13. doi: 10.1172/JCI13103. J Clin Invest. 2001. PMID: 11602628 Free PMC article.

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