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Staging of Alzheimer's disease-related neurofibrillary changes.
Braak H, Braak E. Braak H, et al. Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84. doi: 10.1016/0197-4580(95)00021-6. Neurobiol Aging. 1995. PMID: 7566337 Review.
Microglial activation occurs late during preclinical Alzheimer's disease.
Streit WJ, Braak H, Del Tredici K, Leyh J, Lier J, Khoshbouei H, Eisenlöffel C, Müller W, Bechmann I. Streit WJ, et al. Glia. 2018 Dec;66(12):2550-2562. doi: 10.1002/glia.23510. Epub 2018 Nov 11. Glia. 2018. PMID: 30417428
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature.
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Nelson PT, et al. J Neuropathol Exp Neurol. 2012 May;71(5):362-81. doi: 10.1097/NEN.0b013e31825018f7. J Neuropathol Exp Neurol. 2012. PMID: 22487856 Free PMC article. Review.
Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium.
Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H, Bugiani O, Del-Tredici K, Ferrer I, Gelpi E, Giaccone G, Graeber MB, Ince P, Kamphorst W, King A, Korkolopoulou P, Kovács GG, Larionov S, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Seilhean D, Tagliavini F, Stadelmann C, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H. Alafuzoff I, et al. Brain Pathol. 2008 Oct;18(4):484-96. doi: 10.1111/j.1750-3639.2008.00147.x. Epub 2008 Mar 26. Brain Pathol. 2008. PMID: 18371174 Free PMC article. Clinical Trial.
Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages.
Ghebremedhin E, Thal DR, Schultz C, Braak H, Deller T. Ghebremedhin E, et al. Acta Neuropathol. 2007 Oct;114(4):359-63. doi: 10.1007/s00401-007-0276-8. Epub 2007 Aug 16. Acta Neuropathol. 2007. PMID: 17701416
Role of protein kinase B in Alzheimer's neurofibrillary pathology.
Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Pei JJ, et al. Acta Neuropathol. 2003 Apr;105(4):381-92. doi: 10.1007/s00401-002-0657-y. Epub 2002 Dec 18. Acta Neuropathol. 2003. PMID: 12624792
We found that the amount of activated PKB (p-Thr308) increased in correlation to the progressive sequence of AT8 immunoreactivity and neurofibrillary changes assessed according to Braak's criteria. ...
We found that the amount of activated PKB (p-Thr308) increased in correlation to the progressive sequence of AT8 immunoreactivity and neurof …
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.
Pei JJ, Braak H, An WL, Winblad B, Cowburn RF, Iqbal K, Grundke-Iqbal I. Pei JJ, et al. Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):45-55. doi: 10.1016/s0169-328x(02)00488-6. Brain Res Mol Brain Res. 2002. PMID: 12531514
In the present study, we determined the intracellular and regional distribution of the active forms of both MEK1/2 and ERK1/2, i.e. p-MEK1/2 and p-ERK1/2 in the entorhinal, hippocampal, and temporal cortices of 49 brains staged for neurofibrillary changes according to Braak
In the present study, we determined the intracellular and regional distribution of the active forms of both MEK1/2 and ERK1/2, i.e. p-MEK1/2 …
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration.
Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Pei JJ, et al. Acta Neuropathol. 2002 Oct;104(4):369-76. doi: 10.1007/s00401-002-0565-1. Epub 2002 May 25. Acta Neuropathol. 2002. PMID: 12200623
Using brains staged according to Braak and Braak criteria, we investigated the role of cdc2 in neurofibrillary changes in the hippocampal formation, and the entorhinal and temporal cortices. ...
Using brains staged according to Braak and Braak criteria, we investigated the role of cdc2 in neurofibrillary changes in the …
Microbes and Alzheimer's Disease.
Itzhaki RF, Lathe R, Balin BJ, Ball MJ, Bearer EL, Braak H, Bullido MJ, Carter C, Clerici M, Cosby SL, Del Tredici K, Field H, Fulop T, Grassi C, Griffin WS, Haas J, Hudson AP, Kamer AR, Kell DB, Licastro F, Letenneur L, Lövheim H, Mancuso R, Miklossy J, Otth C, Palamara AT, Perry G, Preston C, Pretorius E, Strandberg T, Tabet N, Taylor-Robinson SD, Whittum-Hudson JA. Itzhaki RF, et al. J Alzheimers Dis. 2016;51(4):979-84. doi: 10.3233/JAD-160152. J Alzheimers Dis. 2016. PMID: 26967229 Free PMC article. Review. No abstract available.
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