Braakman I[au] - Search Results

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The Folding Pathway of ABC Transporter CFTR: Effective and Robust.

van der Sluijs P, Hoelen H, Schmidt A, Braakman I. van der Sluijs P, et al. Among authors: braakman i. J Mol Biol. 2024 Jul 15;436(14):168591. doi: 10.1016/j.jmb.2024.168591. Epub 2024 Apr 26. J Mol Biol. 2024. PMID: 38677493 Free article. Review.

Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator.

Kleizen B, de Mattos E, Papaioannou O, Monti M, Tartaglia GG, van der Sluijs P, Braakman I. Kleizen B, et al. Among authors: braakman i. Int J Mol Sci. 2023 Oct 30;24(21):15741. doi: 10.3390/ijms242115741. Int J Mol Sci. 2023. PMID: 37958724 Free PMC article.

Neil J. Bulleid (1960-2023), a virtuoso of protein folding and redox biology.

Braakman I, High S, Kadler K, Sitia R, Tokatlidis K, Woodman P. Braakman I, et al. EMBO J. 2023 Sep 4;42(17):e115046. doi: 10.15252/embj.2023115046. Epub 2023 Aug 2. EMBO J. 2023. PMID: 37530578 Free PMC article. No abstract available.

ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway.

Im J, Hillenaar T, Yeoh HY, Sahasrabudhe P, Mijnders M, van Willigen M, Hagos A, de Mattos E, van der Sluijs P, Braakman I. Im J, et al. Among authors: braakman i. Cell Mol Life Sci. 2023 Jan 7;80(1):33. doi: 10.1007/s00018-022-04671-x. Cell Mol Life Sci. 2023. PMID: 36609925 Free PMC article.

Redefining Hypo- and Hyper-Responding Phenotypes of CFTR Mutants for Understanding and Therapy.

Hillenaar T, Beekman J, van der Sluijs P, Braakman I. Hillenaar T, et al. Among authors: braakman i. Int J Mol Sci. 2022 Dec 2;23(23):15170. doi: 10.3390/ijms232315170. Int J Mol Sci. 2022. PMID: 36499495 Free PMC article.

Hold the fold: how delayed folding aids protein secretion.

McCaul N, Braakman I. McCaul N, et al. Among authors: braakman i. EMBO J. 2022 Dec 1;41(23):e112787. doi: 10.15252/embj.2022112787. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314692 Free PMC article.

Structure basis of CFTR folding, function and pharmacology.

Hwang TC, Braakman I, van der Sluijs P, Callebaut I. Hwang TC, et al. Among authors: braakman i. J Cyst Fibros. 2023 Mar;22 Suppl 1:S5-S11. doi: 10.1016/j.jcf.2022.09.010. Epub 2022 Oct 8. J Cyst Fibros. 2023. PMID: 36216744

Schistoscope: An Automated Microscope with Artificial Intelligence for Detection of Schistosoma haematobium Eggs in Resource-Limited Settings.

Oyibo P, Jujjavarapu S, Meulah B, Agbana T, Braakman I, van Diepen A, Bengtson M, van Lieshout L, Oyibo W, Vdovine G, Diehl JC. Oyibo P, et al. Among authors: braakman i. Micromachines (Basel). 2022 Apr 19;13(5):643. doi: 10.3390/mi13050643. Micromachines (Basel). 2022. PMID: 35630110 Free PMC article.

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint.

McCaul N, Quandte M, Bontjer I, van Zadelhoff G, Land A, Crooks ET, Binley JM, Sanders RW, Braakman I. McCaul N, et al. Among authors: braakman i. Cell Rep. 2021 Aug 31;36(9):109646. doi: 10.1016/j.celrep.2021.109646. Cell Rep. 2021. PMID: 34469718 Free article.

The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue.

Sabusap CM, Joshi D, Simhaev L, Oliver KE, Senderowitz H, van Willigen M, Braakman I, Rab A, Sorscher EJ, Hong JS. Sabusap CM, et al. Among authors: braakman i. J Biol Chem. 2021 Jan-Jun;296:100598. doi: 10.1016/j.jbc.2021.100598. Epub 2021 Mar 26. J Biol Chem. 2021. PMID: 33781744 Free PMC article.

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