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The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum.
McMahon AP, Joyner AL, Bradley A, McMahon JA. McMahon AP, et al. Cell. 1992 May 15;69(4):581-95. doi: 10.1016/0092-8674(92)90222-x. Cell. 1992. PMID: 1534034
Thus, the observed neonatal phenotype is explained by a series of early events, within 48 hr of neural plate induction, that leads to a complete loss of En domains in the anterior central nervous system. ...We suggest that functional redundancy between these two gen …
Thus, the observed neonatal phenotype is explained by a series of early events, within 48 hr of neural plate induction, that leads to …
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Zheng B, Albrecht U, Kaasik K, Sage M, Lu W, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC. Zheng B, et al. Cell. 2001 Jun 1;105(5):683-94. doi: 10.1016/s0092-8674(01)00380-4. Cell. 2001. PMID: 11389837
Mice carrying a null mutation in the Period 1 (mPer1) gene were generated using embryonic stem cell technology. Homozygous mPer1 mutants display a shorter circadian period with reduced precision and stability. ...Studies of clock-controlled genes (CCGs) reveal a
Mice carrying a null mutation in the Period 1 (mPer1) gene were generated using embryonic stem cell technology. Homozygous mPer1 muta …
Disruption of muscle architecture and myocardial degeneration in mice lacking desmin.
Milner DJ, Weitzer G, Tran D, Bradley A, Capetanaki Y. Milner DJ, et al. J Cell Biol. 1996 Sep;134(5):1255-70. doi: 10.1083/jcb.134.5.1255. J Cell Biol. 1996. PMID: 8794866 Free PMC article.
Desmin, the muscle specific intermediate filament (IF) protein encoded by a single gene, is expressed in all muscle tissues. ...However, these mice demonstrated a multisystem disorder involving cardiac, skeletal, and smooth muscle. Histological and electron microsco …
Desmin, the muscle specific intermediate filament (IF) protein encoded by a single gene, is expressed in all muscle tissues. ...Howev …
The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages.
Martin JF, Bradley A, Olson EN. Martin JF, et al. Genes Dev. 1995 May 15;9(10):1237-49. doi: 10.1101/gad.9.10.1237. Genes Dev. 1995. PMID: 7758948
To determine the functions of MHox, we generated a loss-of-function mutation in the MHox gene. Mice homozygous for a mutant MHox allele die soon after birth and exhibit defects of skeletogenesis, involving the loss or malformation of craniofacial, limb, and vertebra …
To determine the functions of MHox, we generated a loss-of-function mutation in the MHox gene. Mice homozygous for a mutant MH …
Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene.
Hasty P, O'Neal WK, Liu KQ, Morris AP, Bebok Z, Shumyatsky GB, Jilling T, Sorscher EJ, Bradley A, Beaudet AL. Hasty P, et al. Somat Cell Mol Genet. 1995 May;21(3):177-87. doi: 10.1007/BF02254769. Somat Cell Mol Genet. 1995. PMID: 7482032
Mice with a termination codon mutation in exon 2 of the cystic fibrosis (CF) gene were generated using homologous recombination in embryonic stem cells. Animals homozygous for the mutant allele display a severe intestinal phenotype similar to that previously reporte …
Mice with a termination codon mutation in exon 2 of the cystic fibrosis (CF) gene were generated using homologous recombination in em …
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A. Donehower LA, et al. Nature. 1992 Mar 19;356(6366):215-21. doi: 10.1038/356215a0. Nature. 1992. PMID: 1552940
To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous d …
To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by h …
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.
McMahon AP, Bradley A. McMahon AP, et al. Cell. 1990 Sep 21;62(6):1073-85. doi: 10.1016/0092-8674(90)90385-r. Cell. 1990. PMID: 2205396
To examine the role of Wnt-1, we generated six independent embryonic stem cell lines in which insertion of a neoR gene by homologous recombination inactivated a Wnt-1 allele. ...Thus the normal role of Wnt-1 is in determination or subsequent development of a
To examine the role of Wnt-1, we generated six independent embryonic stem cell lines in which insertion of a neoR gene by homologous …
The Wnt family of cell signalling molecules in postimplantation development of the mouse.
McMahon AP, Gavin BJ, Parr B, Bradley A, McMahon JA. McMahon AP, et al. Ciba Found Symp. 1992;165:199-212; discussion 212-8. doi: 10.1002/9780470514221.ch12. Ciba Found Symp. 1992. PMID: 1516469 Review.
The mammalian Wnt gene family consists of at least ten members, all of which share a common structure. The N-terminus encodes a putative signal peptide sequence, suggesting that Wnt proteins are secreted. ...We propose that the Wnt family plays a major role i …
The mammalian Wnt gene family consists of at least ten members, all of which share a common structure. The N-terminus encodes a
Gene targeting in mouse embryonic stem cells with an adenoviral vector.
Mitani K, Wakamiya M, Hasty P, Graham FL, Bradley A, Caskey CT. Mitani K, et al. Somat Cell Mol Genet. 1995 Jul;21(4):221-31. doi: 10.1007/BF02255777. Somat Cell Mol Genet. 1995. PMID: 8525428
We examined the ability of an E1, E3-defective adenoviral vector to act as a substrate for homologous recombination with chromosomal DNA by including host chromosomal sequence from the mouse Fgr locus that also contained a selectable marker. ...Our results suggest t …
We examined the ability of an E1, E3-defective adenoviral vector to act as a substrate for homologous recombination with chromosomal …
Mutation of N-myc in mice: what does the phenotype tell us?
Davis A, Bradley A. Davis A, et al. Bioessays. 1993 Apr;15(4):273-5. doi: 10.1002/bies.950150408. Bioessays. 1993. PMID: 8517856
Oncogenesis is manifested as uncontrolled cellular proliferation and in some situations a failure of normal differentiation in the transformed cell. ...However, these reports make it clear that morphological and histological abnormalities in N-myc mutant mice serve as a
Oncogenesis is manifested as uncontrolled cellular proliferation and in some situations a failure of normal differentiation in the tr …
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