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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.
Jones SN, Roe AE, Donehower LA, Bradley A. Jones SN, et al. Among authors: bradley a. Nature. 1995 Nov 9;378(6553):206-8. doi: 10.1038/378206a0. Nature. 1995. PMID: 7477327
The Mdm2 proto-oncogene was originally identified as one of several genes contained on a mouse double minute chromosome present in a transformed derivative of 3T3 cells. ...These results suggest that a critical role of Mdm2 in development is the regulation of …
The Mdm2 proto-oncogene was originally identified as one of several genes contained on a mouse double minute chromosome present in …
Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.
Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ, Harrow J, Grafham D, Hentges KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR, Funato Y, Miki H, Marin-Garcia P, Matthews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J, Bradley A, Adams DJ, Justice MJ. Boles MK, et al. Among authors: bradley a. PLoS Genet. 2009 Dec;5(12):e1000759. doi: 10.1371/journal.pgen.1000759. Epub 2009 Dec 11. PLoS Genet. 2009. PMID: 20011118 Free PMC article.
An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene annotation of mouse Chromosome 11 was used to test the efficacy of large-scale sequencing for mutation identification. …
An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete …
A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
Boles MK, Wilkinson BM, Maxwell A, Lai L, Mills AA, Nishijima I, Salinger AP, Moskowitz I, Hirschi KK, Liu B, Bradley A, Justice MJ. Boles MK, et al. Among authors: bradley a. BMC Genet. 2009 Mar 6;10:12. doi: 10.1186/1471-2156-10-12. BMC Genet. 2009. PMID: 19267930 Free PMC article.
BACKGROUND: ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of th …
BACKGROUND: ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the …
A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice.
Yu YE, Morishima M, Pao A, Wang DY, Wen XY, Baldini A, Bradley A. Yu YE, et al. Among authors: bradley a. Genetics. 2006 May;173(1):297-307. doi: 10.1534/genetics.105.054833. Epub 2006 Feb 19. Genetics. 2006. PMID: 16489219 Free PMC article.
To attain functional information about this syntenic segment in mice, we have generated a 6.9-Mb deletion [Df(11)18], the reciprocal duplication [Dp(11)18] between Mpo and Chad (the chondroadherin gene), and a 1.8-Mb deletion between Chad and HoxB1. ...Therefore, we …
To attain functional information about this syntenic segment in mice, we have generated a 6.9-Mb deletion [Df(11)18], the reciprocal …
Novel lethal mouse mutants produced in balancer chromosome screens.
Hentges KE, Nakamura H, Furuta Y, Yu Y, Thompson DM, O'Brien W, Bradley A, Justice MJ. Hentges KE, et al. Among authors: bradley a. Gene Expr Patterns. 2006 Aug;6(6):653-65. doi: 10.1016/j.modgep.2005.11.015. Epub 2006 Feb 8. Gene Expr Patterns. 2006. PMID: 16466971
Mutagenesis screens are a valuable method to identify genes that are required for normal development. Previous mouse mutagenesis screens for lethal mutations were targeted at specific time points or for developmental processes. ...We have characterized the mutant lines to …
Mutagenesis screens are a valuable method to identify genes that are required for normal development. Previous mouse mutagenesis scre …
Two new mouse chromosome 11 balancers.
Klysik J, Dinh C, Bradley A. Klysik J, et al. Among authors: bradley a. Genomics. 2004 Feb;83(2):303-10. doi: 10.1016/j.ygeno.2003.08.011. Genomics. 2004. PMID: 14706459
A dominantly acting K14-agouti minigene tags both rearrangements, which enables these balancer chromosomes to be visibly tracked in mouse stocks. ...
A dominantly acting K14-agouti minigene tags both rearrangements, which enables these balancer chromosomes to be visibly tracked in m
Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes.
Chen YT, Liu P, Bradley A. Chen YT, et al. Among authors: bradley a. Mol Cell Biol. 2004 Nov;24(22):9930-41. doi: 10.1128/MCB.24.22.9930-9941.2004. Mol Cell Biol. 2004. PMID: 15509795 Free PMC article.
We designed a selection scheme with drug selection markers and Cre/loxP technology which allows screening of gene trap events that responded to a signaling molecule in a 96-well format. ...Furthermore, we demonstrate that the cre reporter is extremely sensiti …
We designed a selection scheme with drug selection markers and Cre/loxP technology which allows screening of gene trap events that re …
COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.
Yan J, Walz K, Nakamura H, Carattini-Rivera S, Zhao Q, Vogel H, Wei N, Justice MJ, Bradley A, Lupski JR. Yan J, et al. Among authors: bradley a. Mol Cell Biol. 2003 Oct;23(19):6798-808. doi: 10.1128/mcb.23.19.6798-6808.2003. Mol Cell Biol. 2003. PMID: 12972600 Free PMC article.
Csn3 (Cops3) maps to the mouse chromosome 11 region syntenic to the common deletion interval for the Smith-Magenis syndrome, a contiguous gene deletion syndrome. ...We disrupted the murine Csn3 gene in three independent ways with insertional vectors, including constructing …
Csn3 (Cops3) maps to the mouse chromosome 11 region syntenic to the common deletion interval for the Smith-Magenis syndrome, a contig …
Functional genetic analysis of mouse chromosome 11.
Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Kile BT, et al. Among authors: bradley a. Nature. 2003 Sep 4;425(6953):81-6. doi: 10.1038/nature01865. Nature. 2003. PMID: 12955145
To examine genes conserved between human and mouse, we performed a recessive ENU mutagenesis screen that uses a balancer chromosome, inversion chromosome 11 (refs 4, 5). ...This genetic strategy efficiently generates and maps mutations on a single chromosome, …
To examine genes conserved between human and mouse, we performed a recessive ENU mutagenesis screen that uses a balancer chrom …
Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p.
Nishijima I, Mills A, Qi Y, Mills M, Bradley A. Nishijima I, et al. Among authors: bradley a. Genesis. 2003 Jul;36(3):142-8. doi: 10.1002/gene.10207. Genesis. 2003. PMID: 12872245
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