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Site-directed mutagenesis in the mouse.
Bradley A. Bradley A. Recent Prog Horm Res. 1993;48:237-51. doi: 10.1016/b978-0-12-571148-7.50012-9. Recent Prog Horm Res. 1993. PMID: 8441849 Review. No abstract available.
Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.
Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ, Harrow J, Grafham D, Hentges KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR, Funato Y, Miki H, Marin-Garcia P, Matthews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J, Bradley A, Adams DJ, Justice MJ. Boles MK, et al. Among authors: bradley a. PLoS Genet. 2009 Dec;5(12):e1000759. doi: 10.1371/journal.pgen.1000759. Epub 2009 Dec 11. PLoS Genet. 2009. PMID: 20011118 Free PMC article.
An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene annotation of mouse Chromosome 11 was used to test the efficacy of large-scale sequencing for mutation identification. …
An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete …
A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
Boles MK, Wilkinson BM, Maxwell A, Lai L, Mills AA, Nishijima I, Salinger AP, Moskowitz I, Hirschi KK, Liu B, Bradley A, Justice MJ. Boles MK, et al. Among authors: bradley a. BMC Genet. 2009 Mar 6;10:12. doi: 10.1186/1471-2156-10-12. BMC Genet. 2009. PMID: 19267930 Free PMC article.
BACKGROUND: ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of th …
BACKGROUND: ENU-mutagenesis is a powerful technique to identify genes regulating mammalian development. To functionally annotate the …
Novel lethal mouse mutants produced in balancer chromosome screens.
Hentges KE, Nakamura H, Furuta Y, Yu Y, Thompson DM, O'Brien W, Bradley A, Justice MJ. Hentges KE, et al. Among authors: bradley a. Gene Expr Patterns. 2006 Aug;6(6):653-65. doi: 10.1016/j.modgep.2005.11.015. Epub 2006 Feb 8. Gene Expr Patterns. 2006. PMID: 16466971
Mutagenesis screens are a valuable method to identify genes that are required for normal development. Previous mouse mutagenesis screens for lethal mutations were targeted at specific time points or for developmental processes. ...We have characterized the mutant lines to …
Mutagenesis screens are a valuable method to identify genes that are required for normal development. Previous mouse mutagenesis scre …
Two new mouse chromosome 11 balancers.
Klysik J, Dinh C, Bradley A. Klysik J, et al. Among authors: bradley a. Genomics. 2004 Feb;83(2):303-10. doi: 10.1016/j.ygeno.2003.08.011. Genomics. 2004. PMID: 14706459
A dominantly acting K14-agouti minigene tags both rearrangements, which enables these balancer chromosomes to be visibly tracked in mouse stocks. ...
A dominantly acting K14-agouti minigene tags both rearrangements, which enables these balancer chromosomes to be visibly tracked in m
Bigenic Cre/loxP, puDeltatk conditional genetic ablation.
Chen YT, Levasseur R, Vaishnav S, Karsenty G, Bradley A. Chen YT, et al. Among authors: bradley a. Nucleic Acids Res. 2004 Nov 23;32(20):e161. doi: 10.1093/nar/gnh158. Nucleic Acids Res. 2004. PMID: 15561996 Free PMC article.
We describe a two-component conditional ablation technology using a mouse carrying an X-linked puDeltatk transgene, which is only activated in cells expressing Cre. ...This strategy was demonstrated using a Col2Cre transgenic line. Differentiating chondrocyte …
We describe a two-component conditional ablation technology using a mouse carrying an X-linked puDeltatk transgene, which is o …
Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy.
Chan F, Bradley A, Wensel TG, Wilson JH. Chan F, et al. Among authors: bradley a. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9109-14. doi: 10.1073/pnas.0403149101. Epub 2004 Jun 7. Proc Natl Acad Sci U S A. 2004. PMID: 15184660 Free PMC article.
The human rhodopsin-GFP fusion faithfully mimics the expression and distribution of wild-type rhodopsin in heterozygotes and serves as a sensitive reporter of rod-cell structure and integrity. ...GFP-tagged human rhodopsin provides a sensitive method to monitor the …
The human rhodopsin-GFP fusion faithfully mimics the expression and distribution of wild-type rhodopsin in heterozygotes and serves as a
COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.
Yan J, Walz K, Nakamura H, Carattini-Rivera S, Zhao Q, Vogel H, Wei N, Justice MJ, Bradley A, Lupski JR. Yan J, et al. Among authors: bradley a. Mol Cell Biol. 2003 Oct;23(19):6798-808. doi: 10.1128/mcb.23.19.6798-6808.2003. Mol Cell Biol. 2003. PMID: 12972600 Free PMC article.
Csn3 (Cops3) maps to the mouse chromosome 11 region syntenic to the common deletion interval for the Smith-Magenis syndrome, a contiguous gene deletion syndrome. ...We disrupted the murine Csn3 gene in three independent ways with insertional vectors, including constructing …
Csn3 (Cops3) maps to the mouse chromosome 11 region syntenic to the common deletion interval for the Smith-Magenis syndrome, a contig …
Functional genetic analysis of mouse chromosome 11.
Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Kile BT, et al. Among authors: bradley a. Nature. 2003 Sep 4;425(6953):81-6. doi: 10.1038/nature01865. Nature. 2003. PMID: 12955145
To examine genes conserved between human and mouse, we performed a recessive ENU mutagenesis screen that uses a balancer chromosome, inversion chromosome 11 (refs 4, 5). ...This genetic strategy efficiently generates and maps mutations on a single chromosome, …
To examine genes conserved between human and mouse, we performed a recessive ENU mutagenesis screen that uses a balancer chrom …
Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p.
Nishijima I, Mills A, Qi Y, Mills M, Bradley A. Nishijima I, et al. Among authors: bradley a. Genesis. 2003 Jul;36(3):142-8. doi: 10.1002/gene.10207. Genesis. 2003. PMID: 12872245
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