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Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.
Chiche J, Brahimi-Horn MC, Pouysségur J. Chiche J, et al. Among authors: brahimi horn mc. J Cell Mol Med. 2010 Apr;14(4):771-94. doi: 10.1111/j.1582-4934.2009.00994.x. Epub 2009 Dec 8. J Cell Mol Med. 2010. PMID: 20015196 Free PMC article. Review.
Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation.
Brahimi-Horn MC, Giuliano S, Saland E, Lacas-Gervais S, Sheiko T, Pelletier J, Bourget I, Bost F, Féral C, Boulter E, Tauc M, Ivan M, Garmy-Susini B, Popa A, Mari B, Sarry JE, Craigen WJ, Pouysségur J, Mazure NM. Brahimi-Horn MC, et al. Cancer Metab. 2015 Aug 26;3:8. doi: 10.1186/s40170-015-0133-5. eCollection 2015. Cancer Metab. 2015. PMID: 26322231 Free PMC article.
Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia.
Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM. Brahimi-Horn MC, et al. Mol Cell Biol. 2015 May;35(9):1491-505. doi: 10.1128/MCB.01402-14. Epub 2015 Feb 17. Mol Cell Biol. 2015. PMID: 25691661 Free PMC article.
Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy.
Brahimi-Horn MC, Mazure NM. Brahimi-Horn MC, et al. Adv Exp Med Biol. 2014;772:101-10. doi: 10.1007/978-1-4614-5915-6_5. Adv Exp Med Biol. 2014. PMID: 24272356 Review.
Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance.
Brahimi-Horn MC, Ben-Hail D, Ilie M, Gounon P, Rouleau M, Hofman V, Doyen J, Mari B, Shoshan-Barmatz V, Hofman P, Pouysségur J, Mazure NM. Brahimi-Horn MC, et al. Cancer Res. 2012 Apr 15;72(8):2140-50. doi: 10.1158/0008-5472.CAN-11-3940. Epub 2012 Mar 2. Cancer Res. 2012. PMID: 22389449 Free article.
Hypoxia and energetic tumour metabolism.
Brahimi-Horn MC, Bellot G, Pouysségur J. Brahimi-Horn MC, et al. Curr Opin Genet Dev. 2011 Feb;21(1):67-72. doi: 10.1016/j.gde.2010.10.006. Epub 2010 Nov 11. Curr Opin Genet Dev. 2011. PMID: 21074987 Review.
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli.
Chiche J, Rouleau M, Gounon P, Brahimi-Horn MC, Pouysségur J, Mazure NM. Chiche J, et al. Among authors: brahimi horn mc. J Cell Physiol. 2010 Mar;222(3):648-57. doi: 10.1002/jcp.21984. J Cell Physiol. 2010. PMID: 19957303
Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration.
Chiche J, Ilc K, Brahimi-Horn MC, Pouysségur J. Chiche J, et al. Among authors: brahimi horn mc. Adv Enzyme Regul. 2010;50(1):20-33. doi: 10.1016/j.advenzreg.2009.10.005. Epub 2009 Nov 4. Adv Enzyme Regul. 2010. PMID: 19895836 Review. No abstract available.
HIF at a glance.
Brahimi-Horn MC, Pouysségur J. Brahimi-Horn MC, et al. J Cell Sci. 2009 Apr 15;122(Pt 8):1055-7. doi: 10.1242/jcs.035022. J Cell Sci. 2009. PMID: 19339544 Review. No abstract available.
A dialogue between the hypoxia-inducible factor and the tumor microenvironment.
Dayan F, Mazure NM, Brahimi-Horn MC, Pouysségur J. Dayan F, et al. Cancer Microenviron. 2008 Dec;1(1):53-68. doi: 10.1007/s12307-008-0006-3. Epub 2008 Mar 19. Cancer Microenviron. 2008. PMID: 19308685 Free PMC article.
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