Anticoagulation-Related Nephropathy: The Most Common Diagnosis You've Never Heard Of

Am J Med. 2019 Aug;132(8):e631-e633. doi: 10.1016/j.amjmed.2019.02.038. Epub 2019 Mar 13.

Abstract

Anticoagulation-related nephropathy might just be the most common diagnosis you've never heard of. It was formerly known as warfarin-induced nephropathy, until it was observed with numerous other anticoagulants and broadened to anticoagulation-related nephropathy. It is a potentially devastating disorder with serious and life-changing consequences if not recognized and diagnosed swiftly. As the clinician is faced with new acute renal failure, it is important to appreciate those factors that place patients at greater risk of anticoagulation-related nephropathy: conditions such as underlying chronic kidney disease patients and supratherapeutic international normalized ratio. Through greater understanding of this common yet under-recognized condition, we become better equipped to diagnose and prognosticate potential patients. Currently, there are no specific guidelines to follow regarding anticoagulation-related nephropathy identification and management; however, it is an entity that is important to remember, especially given the number of patients requiring anticoagulation for numerous conditions.

Keywords: Acute kidney disease; Anticoagulation; Anticoagulation-related nephropathy; Chronic kidney disease.

Publication types

  • Review

MeSH terms

  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Factor Xa Inhibitors / adverse effects
  • Factor Xa Inhibitors / therapeutic use
  • Humans
  • International Normalized Ratio / classification
  • Renal Insufficiency, Chronic / etiology*
  • Renal Insufficiency, Chronic / physiopathology
  • Risk Factors

Substances

  • Anticoagulants
  • Factor Xa Inhibitors