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T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains.
Brdiĉka T, Cerný J, Horejŝí V. Brdiĉka T, et al. Biochem Biophys Res Commun. 1998 Jul 20;248(2):356-60. doi: 10.1006/bbrc.1998.8857. Biochem Biophys Res Commun. 1998. PMID: 9675140
Stimulation of human T cell line Jurkat results in rapid tyrosine phosphorylation of a 35-38 kDa protein that is found in large and buoyant detergent-resistant membrane microdomains containing also glycosylphosphatidylinositol (GPI)-anchored proteins, glycolipids and Src-f …
Stimulation of human T cell line Jurkat results in rapid tyrosine phosphorylation of a 35-38 kDa protein that is found in large and b …
Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging.
Lukeš T, Glatzová D, Kvíčalová Z, Levet F, Benda A, Letschert S, Sauer M, Brdička T, Lasser T, Cebecauer M. Lukeš T, et al. Among authors: brdicka t. Nat Commun. 2017 Nov 23;8(1):1731. doi: 10.1038/s41467-017-01857-x. Nat Commun. 2017. PMID: 29170394 Free PMC article.
The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells.
Kralova J, Fabisik M, Pokorna J, Skopcova T, Malissen B, Brdicka T. Kralova J, et al. J Biol Chem. 2016 Aug 5;291(32):16530-40. doi: 10.1074/jbc.M116.717157. Epub 2016 Jun 10. J Biol Chem. 2016. PMID: 27288407 Free PMC article.
PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, Otahal P, Alberich-Jorda M, Brdicka T. Drobek A, et al. J Immunol. 2015 Oct 1;195(7):3416-26. doi: 10.4049/jimmunol.1401494. Epub 2015 Aug 24. J Immunol. 2015. PMID: 26304991
L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration.
Serrano-Pertierra E, Cernuda-Morollón E, Brdička T, Hoøejši V, López-Larrea C. Serrano-Pertierra E, et al. J Leukoc Biol. 2014 Sep;96(3):437-45. doi: 10.1189/jlb.2A1013-564R. Epub 2014 May 6. J Leukoc Biol. 2014. PMID: 24803550 Free PMC article.
The involvement of these structures in the biology of T cells, namely in signal transduction by the TCR, has been widely studied. ...
The involvement of these structures in the biology of T cells, namely in signal transduction by the TCR, has been widely studied. ...
LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.
Draber P, Stepanek O, Hrdinka M, Drobek A, Chmatal L, Mala L, Ormsby T, Angelisova P, Horejsi V, Brdicka T. Draber P, et al. J Biol Chem. 2012 Jun 29;287(27):22812-21. doi: 10.1074/jbc.M112.339143. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22589543 Free PMC article.
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T. Draber P, et al. Mol Cell Biol. 2011 Nov;31(22):4550-62. doi: 10.1128/MCB.05817-11. Epub 2011 Sep 19. Mol Cell Biol. 2011. PMID: 21930792 Free PMC article.
Formation of the immunological synapse between an antigen-presenting cell (APC) and a T cell leads to signal generation in both cells involved. In T cells, the lipid raft-associated transmembrane adaptor protein LAT plays a central role. Its phosphorylation is a cru …
Formation of the immunological synapse between an antigen-presenting cell (APC) and a T cell leads to signal generation in both cells …
Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.
Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T. Stepanek O, et al. J Biol Chem. 2011 Jun 24;286(25):22101-12. doi: 10.1074/jbc.M110.196733. Epub 2011 May 4. J Biol Chem. 2011. PMID: 21543337 Free PMC article.
Hypothetical explanations for the difference between T cells and other leukocyte lineages include the inability of CD148 to dephosphorylate a specific set of SFKs involved in T cell activation or the lack of CD148 expression during critical stages of T cell d …
Hypothetical explanations for the difference between T cells and other leukocyte lineages include the inability of CD148 to dephospho …
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